The aim of the study was to perform a retrospective analysis of the morbidity of patients with allergic reactions hospitalized in the department of oral and maxillofacial surgery of the Institute of Emergency Medicine in Chisinau during 2015—2019. To achieve the aim, the medical records of 263 patients, hospitalized during the evaluated period, were studied. It was revealed that the frequency of patients with drug allergies accounted for 3% of the total number of patients hospitalized in the department of oral and maxillofacial surgery during 2015—2019. The analysis of statistical data found an increased incidence of drug allergy in women, most of them with various chronic diseases and allergy to a single drug. A higher frequency of hypersensitivity to local anesthetics was recorded in the group of amidine derivatives (72%).