The core issue of sustainable development refers to the coordinated development of economic-social-environmental issues. In the present study, by complying with the China Sustainable Development Indicator System (CSDIS) concept, a comprehensive index system was built; besides, Natural Breaks (Jenks) Classification Method, Exploratory Spatial Data Analysis and Geographic Detector Analysis were conducted to delve into the sustainability and coordinated degree at city level in China from 2007 to 2017. The achieved results are presented as follows. First, for spatial differentiation, the overall spatial distribution pattern was characterized by the high-value units in eastern China and the low-value units in western China from 2007 to 2017. To be specific, the high-value units were radiated along the Beijing-Guangdong Axis (Jing-Guang Axis) centered on the core of Beijing-Tianjin-Hebei Region, the middle-value units were distributed in strips along the coast, and the low-value units were vastly gathered in western China and gradually break via the Hu Huanyong line (Hu Line) in south China from 2007 to 2017. More specifically, based on the five subsystems, the pattern of each system was consistent with the whole, whereas the degree of concentration was different. Second, for spatial correlation, the significant High-High (HH) areas were primarily distributed in the core of Beijing-Tianjin-Hebei, Yangtze River Delta and Pearl River Delta Regions. The significant Low-Low (LL) areas were continuously distributed in the southwest China and broke through the Hu Line from 2007 to 2017. There were insufficient number of significant High-Low (HL) and significant Low-High (LH) areas, whereas the spatial agglomeration of them was less obvious. Third, for internal coupling coordination, the spatial differentiation between the coupling degree and the coupling coordinated degree was significantly consistent in 2007 and 2017. The Beijing-Tianjin-Hebei, Yangtze River Delta and Pearl River Delta Regions have demonstrated a high level of coordinated evolution, and the pattern of western mountainous areas exhibited a low degree of coordinated growth. Lastly, based on the combination of quantitative and qualitative, its factors were underpinned by robust economic strength, the vitality support of the information level and the basic support function of the topography, active guidance of national policies and path dependence and industrial transfer.