The article examines the factors influencing the growth of the economic potential of machine-building enterprises through an in-depth analysis of industry trends. The volumes of sold products of machine-building enterprises are analyzed. It was found that business leaders skillfully set up production with a long production cycle, which allows businesses in the machine-building industry to ensure the stability of production processes and continuity in the supply of finished products, as the industry is mainly large stages of the product life cycle. The necessity of managing the economic potential of machine-building enterprises by analyzing the indicators of production costs of their products is established. The influence of inflationary processes taking place in the country is taken into account and studied. In the context of macroeconomic preconditions of economic potential management the assets of enterprises of the branch were considered, which characterize its production possibilities and allow estimating the production component of economic potential of machine-building enterprises, and their structure and dynamics reflect spatially oriented nature of enterprise management. The importance of ensuring the processes of digitalization of production potential for the formation of spatial-oriented management of the economic potential of machine-building enterprises is emphasized. The dynamics of capital investment in the acquisition of software by machine-building enterprises indicates the growing role of digital technologies and digital data in the industry, and is one of the main prerequisites for the formation of information potential of enterprises as part of the economic potential. The necessity of taking into account the financial potential as a basis for resource provision of the activity of machine-building enterprises in the management of their economic potential is argued. It was found that the average wage in industry is slightly higher than in Ukraine as a whole, which is due to the knowledge-intensive industry and special working conditions that require the formation of specific human resources, and appropriate pay.