Most literature assumptions have been drawn from public databases e.g. NHANES (National Health and Nutrition Examination Survey). Nonetheless, the sets of data are typically featured by high-dimensional timeliness, heterogeneity, characteristics and irregularity, hence amounting to valuation of these databases not being applied completely. Data Mining (DM) technologies have been the frontiers domains in biomedical studies, as it shows smart routine in assessing patients’ risks and aiding in the process of biomedical research and decision-making in developing disease-forecasting frameworks. In that case, DM has novel merits in biomedical Big Data (BD) studies, mostly in large-scale biomedical datasets. In this paper, a description of DM techniques alongside their fundamental practical applications will be provided. The objectives of this study are to help biomedical researchers to attain intuitive and clear appreciative of the applications of data-mining technologies on biomedical BD to enhance to creation of biomedical results, which are relevant in a biomedical setting.