Modern Developments in the Application and Function of Metal/Metal Oxide Nanocomposite–Based Antibacterial Agents

Mustafa, Yasser Fakri

doi:10.1007/s12668-023-01100-6

Cited by 54 publications

(3 citation statements)

References 113 publications

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“…Compared with organic nanocomposites, inorganic nanomaterials have high stability, large specific surface areas, adjustable structures and sizes, and unique physical and chemical properties, giving them great application prospects in clearing biofilms. Traditional gold and silver antibacterial materials mainly achieve bactericidal effect through the release of metal ions [59], which can be made into nanoparticles to effectively reduce the leakage of metal ions, and can also give the material photothermal, photocatalytic, and photodynamic activities, thus greatly improving the antibiofilm efficiency of the material. In this section, metal-based nanomaterials are classified, and the applications of inorganic nanomaterials in antibiofilms based on gold, silver and other metals are described in detail.…”

Section: Inorganic Nanomaterialsmentioning

confidence: 99%

Recent Advances of Composite Nanomaterials for Antibiofilm Application

Qi,

Cui,

Liu

et al. 2023

Nanomaterials

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A biofilm is a microbial community formed by bacteria that adsorb on the surface of tissues or materials and is wrapped in extracellular polymeric substances (EPS) such as polysaccharides, proteins and nucleic acids. As a protective barrier, the EPS can not only prevent the penetration of antibiotics and other antibacterial agents into the biofilm, but also protect the bacteria in the biofilm from the attacks of the human immune system, making it difficult to eradicate biofilm-related infections and posing a serious threat to public health. Therefore, there is an urgent need to develop new and efficient antibiofilm drugs. Although natural enzymes (lysozyme, peroxidase, etc.) and antimicrobial peptides have excellent bactericidal activity, their low stability in the physiological environment and poor permeability in biofilms limit their application in antibiofilms. With the development of materials science, more and more nanomaterials are being designed to be utilized for antimicrobial and antibiofilm applications. Nanomaterials have great application prospects in antibiofilm because of their good biocompati-bility, unique physical and chemical properties, adjustable nanostructure, high permeability and non-proneness to induce bacterial resistance. In this review, with the application of composite nanomaterials in antibiofilms as the theme, we summarize the research progress of three types of composite nanomaterials, including organic composite materials, inorganic materials and organic–inorganic hybrid materials, used as antibiofilms with non-phototherapy and phototherapy modes of action. At the same time, the challenges and development directions of these composite nanomaterials in antibiofilm therapy are also discussed. It is expected we will provide new ideas for the design of safe and efficient antibiofilm materials.

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Section: Inorganic Nanomaterialsmentioning

confidence: 99%

Recent Advances of Composite Nanomaterials for Antibiofilm Application

Qi,

Cui,

Liu

et al. 2023

Nanomaterials

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“…By the creation of hybrid composites, it becomes possible to maximize the advantages while minimizing the drawbacks associated with individual types of nanoparticles (NPs). Additionally, the “combinatorial” approach allows for an extended duration of effective antibacterial action, significantly reducing bacterial resistance development. , Among the diverse array of nanomaterials available, organic polymerized nanomaterials offer the advantage of pH-responsive antimicrobial properties and the ability to mimic the actions of antimicrobial peptides to combat bacteria. , Inorganic metals, , such as gold , (Au), silver , (Ag), and copper , (Cu), as well as transition metal dichalcogenides (TMDs), metal oxides, , carbon-based nanomaterials, polymers, and their nanocomposites, have all been prominently utilized in the antibacterial research field . These materials operate through distinct antibacterial mechanisms compared with conventional antibiotics and carry a reduced risk of fostering bacterial resistance.…”

Section: Introductionmentioning

confidence: 99%

“… 10 , 16 Among the diverse array of nanomaterials available, organic polymerized nanomaterials offer the advantage of pH-responsive antimicrobial properties and the ability to mimic the actions of antimicrobial peptides to combat bacteria. 17 , 18 Inorganic metals, 7 , 19 such as gold 20 , 21 (Au), silver 22 , 23 (Ag), and copper 24 , 25 (Cu), as well as transition metal dichalcogenides 26 (TMDs), metal oxides, 27 , 28 carbon-based nanomaterials, 29 polymers, and their nanocomposites, have all been prominently utilized in the antibacterial research field. 30 These materials operate through distinct antibacterial mechanisms compared with conventional antibiotics and carry a reduced risk of fostering bacterial resistance.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Molybdenum Oxide–Polyacrylonitrile Composite Membrane with Fast Silver Ion Reduction

Farooq,

Bilal,

Gohar

et al. 2023

ACS Omega

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The development of hybrid composite antibacterial agents for wound dressing has garnered significant attention due to their remarkable antibacterial efficacy and their potential to mitigate microbial resistance. In this study, we present an approach to designing and fabricating wound dressing membranes, utilizing molybdenum oxide–polyacrylonitrile (MoO 3 /PAN) hybrid composites through electrospinning. Subsequently, we enhanced the membrane’s effectiveness by introducing silver (Ag@MoO 3 /PAN) into the matrix via a rapid (within one min) green synthesis method under UV irradiation. Initially, we discuss the morphological characteristics and structural attributes of the resulting membranes. Subsequent investigations explore the antibacterial mechanisms of both MoO 3 and Ag + , revealing that the incorporation of silver substantially enhanced antibacterial activity. Additionally, we elucidate the surface properties, noting that the introduction of silver increases the surface area of the composite membrane by 25.89% compared with the pristine MoO 3 /PAN membrane. Furthermore, we observe a 9% reduction in the water contact angle (WCA) for the Ag@MoO 3 /PAN membrane, indicating improved hydrophilicity. Finally, we analyze the release behavior of the Ag@MoO 3 /PAN membrane. Our findings demonstrate an initial burst release within the first 7 h, followed by a controlled and sustained release pattern over a period of 7 days.

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Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Younes,

Mustafa

2024

Chemistry & Biodiversity

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Plant‐derived coumarin (PDC) is a naturally occurring heterocyclic backbone that belongs to the benzopyrone family. PDC and its based products are characterized by low toxicity and high distribution in a variety of herbal treatments that have numerous therapeutic potentials. These include anticoagulants, antibacterials, anti‐inflammatory agents, anticancer agents, antioxidants, and others. So, it may be appropriate to investigate the qualities and potential bioactivities of PDCs. This article provides an overview of the biomedical potentials, availability, and clinical use possibilities of PDCs, with a focus on their important modes of action, using information on various pharmacological qualities discovered. The data used in this study came from published research between 2015 and 2023. We reviewed a selection of databases, including PubMed, Scopus, Web of Science, and Google Scholar, during that period. In conclusion, because of their abundance in medicinal plants, the clinical biochemistry attributes of PDCs are currently of interest. In a variety of medical specialties, PDCs serve a useful role as therapeutic agents.

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Modern Developments in the Application and Function of Metal/Metal Oxide Nanocomposite–Based Antibacterial Agents

Cited by 54 publications

References 113 publications

Recent Advances of Composite Nanomaterials for Antibiofilm Application

Recent Advances of Composite Nanomaterials for Antibiofilm Application

Antibacterial Activity of Molybdenum Oxide–Polyacrylonitrile Composite Membrane with Fast Silver Ion Reduction

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

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