Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—A Literature Review

Zasadziński, Konrad; Spałek, Mateusz; Rutkowski, Piotr

doi:10.3390/pharmaceutics14061204

Cited by 20 publications

(13 citation statements)

References 70 publications

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“…The material’s flexibility enables the film to conform to complex shapes while facilitating gas exchange, which has been proven to promote healing [ 34 ]. Additionally, its transparency allows for the close monitoring of the wounded area without removing the film, thereby reducing trauma during dressing changes, minimizing exposure to bacteria, and lowering the risk of infection by up to one week [ 34 , 35 ].…”

Section: Polymeric Films For Wound Healingmentioning

confidence: 99%

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Borbolla-Jiménez,

Peña-Corona,

Farah

et al. 2023

Pharmaceutics

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Wound healing is a complex process that involves restoring the structure of damaged tissues through four phases: hemostasis, inflammation, proliferation, and remodeling. Wound dressings are the most common treatment used to cover wounds, reduce infection risk and the loss of physiological fluids, and enhance wound healing. Despite there being several types of wound dressings based on different materials and fabricated through various techniques, polymeric films have been widely employed due to their biocompatibility and low immunogenicity. Furthermore, they are non-invasive, easy to apply, allow gas exchange, and can be transparent. Among different methods for designing polymeric films, solvent casting represents a reliable, preferable, and highly used technique due to its easygoing and relatively low-cost procedure compared to sophisticated methods such as spin coating, microfluidic spinning, or 3D printing. Therefore, this review focuses on the polymeric dressings obtained using this technique, emphasizing the critical manufacturing factors related to pharmaceuticals, specifically discussing the formulation variables necessary to create wound dressings that demonstrate effective performance.

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Section: Polymeric Films For Wound Healingmentioning

confidence: 99%

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Borbolla-Jiménez,

Peña-Corona,

Farah

et al. 2023

Pharmaceutics

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“…In fact, it shows that although rhEGF cannot counteract and reverse the skin reaction caused by radiation dose, it could relieve the pain of radiotherapy and accelerate the healing of skin to some extent. Besides, different types of dressing have been shown as effective ways to prevent and treatment of radiation dermatitis [22]. A combination between rhEGF and dressing may be an efficient treatment, which could be studied in further assessment.…”

Section: Discussionmentioning

confidence: 99%

The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study

et al. 2022

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Background Our previous study reported that recombinant human epidermal growth factor (rhEGF)-triggered EGFR internalization promoted radioresistance. Here, we aimed to evaluate the effect of rhEGF on the skin protection of rectal and anal cancer patients receiving radiotherapy. Methods One hundred and ninety-three rectal and anal cancer patients who received radiotherapy were prospectively enrolled from January 2019 to December 2020. To perform self-controlled study, the left and right pelvic skin area (separated by midline) were randomly assigned to the rhEGF and control side. The association between radiation dermatitis and factors including rhEGF, the dose of radiotherapy and tumor distance from anal edge were analyzed. Results Among 193 enrolled patients, 41 patients (21.2%) did not develop radiation dermatitis, and 152 patients (78.8%) suffered radiation dermatitis on at least one side of pelvic skin at the end of radiotherapy. For the effect on radiation dermatitis grade, rhEGF had improved effect on 6 (4.0%) patients, detrimental effect on 2 (1.3%) patients, and no effect on 144 (94.7%) patients. Whereas for the effect on radiation dermatitis area, rhEGF showed improved effect on the radiation dermatitis area of 46 (30.2%) patients, detrimental effect on 15 (9.9%) patients, and no effect on 91 (59.9%) patients. The radiation dermatitis area of rhEGF side was significantly smaller than that of control side (P = 0.0007). Conclusions rhEGF is a skin protective reagent for rectal and anal cancer patients receiving radiotherapy. Trial registration Chinese Clinical Trial Registry identifier: ChiCTR1900020842; Date of registration: 20/01/2019.

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“…A study utilizing thermal radiation dressings to heat both normal skin on human thighs and surgical wounds (set at 38°C for 2 hours of heating followed by 2 hours of rest, over a period of 7 days) maintained wound temperatures between 36.0-37.5°C. 65 This demonstrated that local heating can enhance microvascular blood flow and subcutaneous oxygen content in both normal and injured skin, potentially offering resistance to infection without increasing collagen deposition at the wound site. In addition, thermal radiation dressings (set at 38°C, three times a day for 1 hour) were used for the treatment of Stage I-II uninfected pressure injuries over 6 weeks or until healing showed that, compared to standard treatment with alginate dressings, this method significantly improved wound healing rates.…”

Section: Pressure Injurymentioning

confidence: 97%

Exploring Thermal Dynamics in Wound Healing: The Impact of Temperature and Microenvironment

Huang,

Fan,

et al. 2024

CCID

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Exploring the critical role of thermal dynamics in wound healing, this manuscript navigates through the complex biological responses initiated upon wound infliction and how temperature variations influence the healing trajectory. Integrating biothermal physics, clinical medicine, and biomedical engineering, it highlights the significance of thermal management in wound care, emphasizing the wound microenvironment's division into internal and external domains and their collaborative impact on tissue repair. Innovations in real-time wound temperature monitoring, especially through intelligent wireless sensor dressings, are spotlighted as transformative, enabling precise wound condition management. The text underscores the necessity for further research to elucidate thermal regulation's molecular and cellular mechanisms on healing processes. It advocates for standardized protocols for localized heating treatments, integrating them into personalized wound care strategies to enhance therapeutic outcomes, improve patient wellbeing, and achieve cost-effective healthcare practices. This work presents a forward-looking perspective on refining wound management through sophisticated, evidence-based interventions, emphasizing the interplay between thermal dynamics and wound healing.

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Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—A Literature Review

Cited by 20 publications

References 70 publications

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Films for Wound Healing Fabricated Using a Solvent Casting Technique

The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study

Exploring Thermal Dynamics in Wound Healing: The Impact of Temperature and Microenvironment

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