Modern Ethiotropic Chemotherapy of Human Cytomegalovirus Infection: Clinical Effectiveness, Molecular Mechanism of Action, Drug Resistance, New Trends and Prospects. Part 1

Андронова, В. Л.

doi:10.18821/0507-4088-2018-63-5-202-211

Cited by 2 publications

(1 citation statement)

References 48 publications

(56 reference statements)

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“…Although ganciclovir has always been the first choice for the treatment of cytomegalovirus infections, it only shows moderate antiviral activity, which is not sufficient to completely inhibit virus replication (27). New therapies such as letermovir are under development (28,29), and we hope to compare the efficacy of ganciclovir and those of other therapeutic schemes or combination therapy in subsequent studies.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of small‑dose ganciclovir on cytomegalovirus infections in children and its effects on liver function and miR‑UL112‑3p expression

et al. 2021

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The aim of the study was to explore the efficacy of small-dose ganciclovir on cytomegalovirus infections as well as its effects on the liver function and miR-UL112-3p of children. A total of 141 children infected with cytomegalovirus admitted to the Affiliated Hospital of Weifang Medical University from May 2015 to August 2017 were enrolled, of which 74 children were treated with small-dose ganciclovir as an observation group (Obs group), and the rest were treated with conventional-dose ganciclovir as a control group (Con group). The two groups were compared in efficacy after treatment, changes of liver function indexes [total bilirubin (TB), alanine aminotransferase (ALT), and aspartate aminotransferase (AST)] and miR-UL112-3p before and after treatment, and adverse reactions after treatment. A receiver operating characteristic (ROC) curve was drawn to analyze the value of miR-UL112-3p in predicating efficacy on cytomegalovirus infections in children, and Pearson's correlation analysis was carried out to analyze the correlation between miR-UL112-3p expression and TB, ALT and AST. The MV-DNA level between the two groups after treatment was compared. The two groups showed no significant difference in efficacy and adverse reactions (both P>0.05), and before treatment, there was also no significant difference between the two groups in miR-UL112-3p, TB, ALT, and AST, while after treatment, both groups showed lower levels of miR-UL112-3p, TB, ALT, and AST, and the Obs group showed significantly lower levels thereof than the Con group (all P<0.05). In addition, the area under the curve (AUC), specificity, and sensitivity of miR-UL112-3p in the ROC curve of the Obs group were 0.866, 73.77 and 84.62%, respectively, while the AUC, specificity, and sensitivity of the ROC of the Con group were 0.837, 75.44, and 90.00%, respectively. Furthermore, miR-UL112-3p was positively correlated with TB, ALT, and AST, respectively. The CMV-DNA level in the Obs group was lower than that in the Con group, but the difference was not significant, and the level of CMV-DNA was positively correlated with that of miR-UL112-3p. In conclusion, small-dose ganciclovir can better improve the liver function of the children, and downregulate miR-UL112-3p in them. The AUC, specificity, and sensitivity of miR-UL112-3p for predicting the efficacy of small-dose ganciclovir were 0.866, 73.77 and 84.62%, respectively, and the AUC, specificity, and sensitivityfor predicting the efficacy of conventional-dose ganciclovir were 0.837, 75.44 and 90.00%, respectively.

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Section: Discussionmentioning

confidence: 99%

Efficacy of small‑dose ganciclovir on cytomegalovirus infections in children and its effects on liver function and miR‑UL112‑3p expression

et al. 2021

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Modern concepts of the mechanisms of congenital cytomegalovirus infection development

Васильев

Рогозина²,

Markin³

2023

jour

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The review presents modern information of domestic and foreign authors about possible pathogenetic mechanisms of the virus effect on the fetus in the case of cytomegalovirus infection in pregnant women. Immunosuppressive changes, which are a feature of the physiological course of pregnancy, create favorable conditions for the development of active cytomegalovirus infection. The virus’s ability to infect a wide range of cells in vivo and trigger a set of molecular mechanisms causes changes in placental cell differentiation, which plays a key role in transplant transmission. The processes of formation of chronic placental insufficiency, which leads to hypoxia of the fetus and to delay of intrauterine development, are separately highlighted. The literary data on non-specific metabolic changes of the mother and placental activation of proinflammatory cytokines (TNF-α, IL-1β, IL2, IL-6 and IL-8), which occur in cytomegalovirus infection and are of significant importance in formation of hypoxia of the fetus have been analyzed.In addition, the role of individual cells in preventing intrauterine infection is examined, namely the deciduous macrophages with antiviral activity, the deciduous natural killers and their activated toll-like receptors. The article also discusses the genetic predisposition to the development of manifest forms of EID, including the relationship of polymorphism of TLR2 and Arg753Gln genes with an increased risk of intrauterine infection of the fetus CMV.Characteristic properties of the virus are pronounced genetic diversity, the ability to life-long persistence in various human organs and tissues (secretory glands, lymphatic cells, kidneys, etc.) and replication without cell damage, as well as suppressing cellular immunity. The article describes the issues of genotyping of virus and the relationship of some genotypes with certain organ pathology in newborns.

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Modern Ethiotropic Chemotherapy of Human Cytomegalovirus Infection: Clinical Effectiveness, Molecular Mechanism of Action, Drug Resistance, New Trends and Prospects. Part 1

Cited by 2 publications

References 48 publications

Efficacy of small‑dose ganciclovir on cytomegalovirus infections in children and its effects on liver function and miR‑UL112‑3p expression

Efficacy of small‑dose ganciclovir on cytomegalovirus infections in children and its effects on liver function and miR‑UL112‑3p expression

Modern concepts of the mechanisms of congenital cytomegalovirus infection development

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