Modern Imaging Techniques in the Study and Disease Diagnosis of the Mammary Glands of Animals

Barbagianni, M.S.; Gouletsou, P.G.

doi:10.3390/vetsci10020083

Cited by 6 publications

(4 citation statements)

References 120 publications

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“…Louder treatment plans, including neoadjuvant systemic therapy, mastectomy and breast reconstruction, postoperative chemotherapy and targeted therapy, are otherwise indicated (tumour >2 cm, positive node or aggressive BC phenotype) (Cardoso et al, 2019). A progress in canine/feline MC management would be achieved if treatment plans were adapted to systematically defined cancer stages by histopathology (tumour, node) and medical imaging (for distant metastases) (Barbagianni & Gouletsou, 2023; Chocteau, Abadie, et al, 2019; Chocteau, Boulay, et al, 2019). The main aim of adapting treatment to cancer stage is to avoid overtreatment of in situ or localized disease, and undertreatment of locoregional or advanced disease.…”

Section: Influence Of the Stage Of Mammary Carcinomas On Treatment Op...mentioning

confidence: 99%

Mammary carcinoma: Comparative oncology between small animals and humans—New therapeutic tools

Frenel

Nguyen

2023

Reprod Domestic Animals

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The poor outcomes associated with mammary carcinomas (MCs) in dogs and cats in terms of locoregional recurrence, distant metastasis and survival, highlight the need for better management of mammary cancers in small animals. By contrast, the outcomes of women with breast cancer (BC) have dramatically improved during the last 10 years, notably thanks to new therapeutic strategies. The aim of this article was to imagine what could be the future of therapy for dogs and cats with MCs if it became inspired from current practices in human BC. This article focuses on the importance of taking into account cancer stage and cancer subtypes in therapeutic plans, on locoregional treatments (surgery, radiation therapy), new developments in endocrine therapy, chemotherapy, PARP inhibitors and immunotherapy. Ideally, multimodal treatment regimens would be chosen according to cancer stage and cancer subtypes, and according to predictive factors that are still to be defined.

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Section: Influence Of the Stage Of Mammary Carcinomas On Treatment Op...mentioning

confidence: 99%

Mammary carcinoma: Comparative oncology between small animals and humans—New therapeutic tools

Frenel

Nguyen

2023

Reprod Domestic Animals

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“…Mice have less number and types of stem cells that can be sufficient to manipulate and analyze in stem cell therapies. The technologies used in mice and human beings to evaluate and monitor neurofunction recovery is different (Barbagianni, M. S. & Gouletsou, P. G., 2023). In addition, the safety of stem cell applications cannot be evaluated in the same way because the dosages of stem cells and the route of administration are very different in mice and human with huge differences in size (Plews, J. R., Gu, M., Longaker, M. T. & Wu, J. C., 2012).…”

Section: Magnetic Stimulationmentioning

confidence: 99%

Spinal Cord Injury: Pathophysiology, Neural Stem Cell Treatment and Its Combination with Other Strategies

Chen

2023

JIMR

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Spinal cord injury is associated with the damage to neural circuits and disruption of neural pathways, leading to irreversible long-term complications in terms of physical and mental health. Traditional treatments mainly include surgical decompression and pharmacotherapy whereas none of them could attenuate or even alleviate long-term complications following SCI. This is largely due to complicated pathophysiological process in SCI which includes primary injury and secondary injury. Primary injury is defined as direct mechanical damage on the spinal cord in the initial time course of injury. Secondary injury occurs a few hours after primary injury and it could persist for longer time, promoting a catastrophe of degenerative pathophysiological process in spinal cord and related tissues. Although currently there is no effective cure strategies for SCI, some recent studies have shown that stem cell therapy combined with other strategies is able to enhance neurofunctional recovery and neural stem cell line is one of the stem cell lines which show convincing therapeutic effects (Huang, L., Fu, C., Xiong, F., He, C. & Wei, Q., 2021). Biomaterials can work as carriers which help deliver nutrient biomolecules to help NSC survive and differentiate to more functional cells or as scaffolds which provide structural bridges to lesion site for NSC migration and tissue regeneration (Vismara, I., Papa, S., Rossi, F., Forloni, G. & Veglianese, P., 2017). In addition, the basic principles of magnetic stimulation and electric stimulation are similar and they all involve producing electrical current on brain or spinal cord to modulate brain or spinal cord activity. It has been revealed that electric stimulation and repetitive magnetic stimulation is associated with neuroplasticity which may reduce inappropriate lateral sprouting resulting from NSC therapy, making them become potential complementary strategies to NSC therapy as well (Kricheldorff, J. et al., 2022).

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“…Although, lymphoscintigraphy is considered the gold standard for lymphatic mapping, it can be studied in different ways, with its advantages and disadvantages. It is cited as methods of lymphatic mapping of the mammary glands, CT lymphography, radiographic lymphography, scintigraphy, as well as the use of vital dyes such as patent blue and methylene (BARBAGIANNI & GOULETSOU, 2023;BEER et al, 2023;FERANTI et al, 2018;SOULTANI et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Medial iliac lymph node as a target for metastasis in bitches with malignant mammary neoplasms

Feranti,

Coradini,

Linhares

et al. 2024

Cienc. Rural

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The regional lymphatic connections of the mammary glands in canines are poorly investigated, both in healthy animals and in those with mammary neoplasms. The objective was to establish the occurrence of metastases in the medial iliac lymph nodes (MILN) in bitches with mammary neoplasm, in addition to evaluating the effectiveness of the technique of lymphatic labeling of the MILN, administering methylene blue (MB) dye intrauterinely or intradermally. Thirty-two bitches with tumors in different mammary glands were included in the study. In 13 bitches (GU group), the MILNs were stained with intrauterine MB, followed by unilateral lymphadenectomy, ovariohysterectomy (OVH) and unilateral mastectomy. Nineteen bitches (GI group) underwent OVH, followed by MILN staining with intradermal MB, lymphadenectomy, and unilateral mastectomy. In GU, 11 bitches (84.62%) exhibited MB-stained MILNs, but staining was not observed in two (15.38%). Metastasis to MILNs was observed in three bitches (9.38%) from the GI and two (6.25%) from the GU. Intrauterine and intradermal staining of MILNs in bitches with mammary tumors was efficient, but intradermal administration of MB produced better results. Given metastatic spread to MILNs in approximately 15.63% of patients, we recommend that screening for MILNs should be considered as part of the staging of animals with malignant mammary neoplasms.

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Modern Imaging Techniques in the Study and Disease Diagnosis of the Mammary Glands of Animals

Cited by 6 publications

References 120 publications

Mammary carcinoma: Comparative oncology between small animals and humans—New therapeutic tools

Mammary carcinoma: Comparative oncology between small animals and humans—New therapeutic tools

Spinal Cord Injury: Pathophysiology, Neural Stem Cell Treatment and Its Combination with Other Strategies

Medial iliac lymph node as a target for metastasis in bitches with malignant mammary neoplasms

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