Modern Methods for the Synthesis of 1,4‐Oxazepanes and their Benzo‐Derivatives

Enantioenriched α-Vinyl 1,4-Benzodiazepines and 1,4-Benzoxazepines via Enantioselective Rhodium-Catalyzed Hydrofunctionalizations of Alkynes and Allenes

“…On the other hand, 1,4-benzo[ e ]oxazepines (1,4-BZOs) possess recognized pharmacological activity in the treatment of Alzheimer disease 8 and as tranquilizers. 9 …”

“…In addition, several drugs and advanced metabolites possess a stereodefined chiral Csp 3 in C-3 (1,4 benzodiazepine numbering), which enhances their biological activity, e.g., the pyrrolobenzodiazepines (PBZDs), bearing a [7,5] ring fusion with an N -bridgehead (Figure ). On the other hand, 1,4-benzo­[ e ]­oxazepines (1,4-BZOs) possess recognized pharmacological activity in the treatment of Alzheimer disease and as tranquilizers …”