Modern physicochemical research on Langmuir monolayers

Dynarowicz-Łątka, Patrycja; Dhanabalan, A.; Oliveira, O.N.

doi:10.1016/s0001-8686(99)00034-2

Cited by 329 publications

(269 citation statements)

References 300 publications

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“…where P (2) ( 1 ϩ 2 ) is the sum-frequency polarization per unit volume induced by two incoming fields E of frequencies 1 and 2 . In the experiments the polarizations of the inand out-coming fields were chosen so as to probe the components xxz (2) ϭ yyz (2) ϵ .…”

Section: P Imentioning

confidence: 99%

“…1 Understanding their behavior is essential for the LangmuirBlodgett technique which involves the formation of a monolayer film on a water surface with subsequent transfer onto a solid substrate. 2 In a biological context phospholipid monolayers are a model system for membrane biophysics, as a lipid bilayer, the basis for a biological membrane, can be considered as two weakly coupled monolayers. 3 Phospholipid monolayers are also used as a model for lung surfactant, a complex mixture of lipid and protein that has been proposed to form a monolayer at the alveolar liquid-air interface.…”

Section: Introductionmentioning

confidence: 99%

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Simulation studies of pore and domain formation in a phospholipid monolayer

Knecht

Müller

Bonn

et al. 2004

The Journal of Chemical Physics

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Simulation studies of pore and domain formation in a phospholipid monolayer.Knecht, V.; Müller, M.; Bonn, M.; Marrink, S.J.; Mark, A.E. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Despite extensive study the phase behavior of phospholipid monolayers at an air-water interface is still not fully understood. In particular recent vibrational sum-frequency generation ͑VSFG͒ spectra of DPPC monolayers as a function of area density show a sharp transition in the order of the lipid chains at 1.10 nm 2 /molecule. This is in a region where the lateral pressure as a function of area is effectively constant. We have investigated the nature of this transition by studying the phase behavior of DPPC monolayers as a function of area density using molecular-dynamics simulations. The changes in order within the monolayer as a function of area density correlate well with the experimental signal. At 0.58 nm 2 /molecule we observe the onset of lateral separation of highly ordered and disordered lipids, indicating the coexistence of a gel-like liquid condensed and a fluidlike liquid expanded phase. At 0.97 nm 2 /molecule the monolayer ruptures, marking the onset of the liquid-gas ͑G͒ coexistence region. This is much earlier than suggested by fluorescence microscopy results and implies that at the point of rupture, the initial pores have an equilibrium size smaller than ϳ500 nm in diameter. The rupture of the monolayer leads to a sharp increase in the overall lipid order that explains the sharp transition observed in the VSFG measurements. VSFG measurements thus may represent a sensitive means to determine the onset of the liquid-gas ͑G͒ coexistence region for such systems.

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Section: P Imentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simulation studies of pore and domain formation in a phospholipid monolayer

Knecht

Müller

Bonn

et al. 2004

The Journal of Chemical Physics

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“…Among the various models of cell membranes, lipid Langmuir monolayers are extensively used because several param-eters, such as lipid composition, subphase properties, pH and temperature can be chosen to imitate real biological conditions (Kaganer et al, 1999;Brezesinski and Möhwald, 2003;Gaboriaud et al, 2005). Moreover, Langmuir monolayers offer the possibility of controlling the molecular organization in a bi-dimensional structure similar to that of the biological membranes (Maget-Dana, 1999;Dynarowicz-Latka et al, 2001). By the film-balance method the surface pressure/mean molecular area ( /Å 2 ) isotherm curves are easily obtained.…”

Section: Introductionmentioning

confidence: 99%

Interaction of acyclovir and its squalenoyl–acyclovir prodrug with DMPC in monolayers at the air/water interface

Sarpietro

Rocco

Micieli

et al. 2010

International Journal of Pharmaceutics

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a b s t r a c tAcyclovir has been conjugated to the acyclic isoprenoid chain of squalene to form the squalenoyl-acyclovir prodrug. Its interaction with biomembrane models constituted by dimyristoylphosphatidylcholine (DMPC) monolayers has been studied by employing the Langmuir-Blodgett technique. The aim of the work was to gain information on the interaction of these compounds with phospholipid membranes.DMPC/acyclovir or squalenoyl-acyclovir prodrug mixed monolayers have been prepared at increasing molar fractions of the compound and the isotherm mean molecular area/surface pressure has been registered at 10 and 37 • C. Results reveal that the squalenoyl moiety enhances the affinity of acyclovir for the biomembrane model.

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“…Among the various types of properties for which the importance of molecular architecture has been demonstrated is the optical storage capability of films containing azobenzene compounds. [7][8][9]. Indeed, several molecular engineering strategies have been used to optimize both order and film thickness of this kind of materials.…”

Section: Introductionmentioning

confidence: 99%