Modern progress and future challenges in nanocarriers for probe applications

Kumar, Pawan; Kim, Ki‐Hyun; Bansal, Vasudha; Kumar, Sandeep; Dilbaghi, Neeraj; Kim, Yong Hyun

doi:10.1016/j.trac.2016.10.005

Cited by 12 publications

(3 citation statements)

References 166 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanocarriers can deliver a wide range of drugs with versatile physicochemical properties [182][183][184]. In contrast, some challenges exist in nanocarrier-based drug delivery, which include poor drug loading capacity, missing cellular uptake ability, toxicity, and questionable biodegradability and ligand-tagging ability [185]. However, formulation scientists have mentioned several approaches to mitigate these limitations and to achieve real-world applications of nanocarrier-based drug delivery.…”

Section: Nanocarrier-based Drug Delivery: a Contemporary Promisementioning

confidence: 99%

“…However, formulation scientists have mentioned several approaches to mitigate these limitations and to achieve real-world applications of nanocarrier-based drug delivery. A recent report revealed that the global market of drug nanoformulations is rising progressively with an annual growth rate of 22% [185].…”

Section: Nanocarrier-based Drug Delivery: a Contemporary Promisementioning

confidence: 99%

See 1 more Smart Citation

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

View full text Add to dashboard Cite

Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

show abstract

Section: Nanocarrier-based Drug Delivery: a Contemporary Promisementioning

confidence: 99%

Section: Nanocarrier-based Drug Delivery: a Contemporary Promisementioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…The proposed underlying mechanisms of antimicrobial effect of terpenes such as citral are the interaction with cytoplasmic membrane resulting in loss of membrane integrity, inhibition of respiratory enzymes, and subsequently dissipation of the proton-motive force ( 15 ). Lipid-based nanocarriers can also facilitate antimicrobial activity of the essential oils by providing diverse diffusion properties trough biological membranes due to nanoscale and lipophilic nature ( 16 ). Addition of encapsulated citral in lipid-based nanoparticles with lower amounts of citral rather than using citral emulsion is not only economical, but also could prevent any changes in the taste and color of foodstuffs.…”

Section: Discussionmentioning

confidence: 99%

Improvement of citral antimicrobial activity by incorporation into nanostructured lipid carriers: A potential application in food stuffs as a natural preservative

et al. 2017

View full text Add to dashboard Cite

At the present time, utilization of essential oils in food preservation to prevent bacterial and fungal growth and improve shelf life and safety of the food products has notably gained increased interest. The aim of the present study was to improve the antimicrobial efficacy of citral as a natural preservative using nanostructured lipid carriers (NLCs). Formulations of NLCs were characterized using particle size analysis and scanning electron microscopy methods. Possible citral-carrier interaction and citral encapsulation efficiency percent (EE%) were assessed by Fourier transform infrared (FTIR) spectroscopy and gas chromatography techniques, respectively. Antimicrobial activity, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of citral-loaded NLCs were evaluated and compared with the conventional citral emulsion against various gram-positive bacteria (Staphylococcus aureus, Bacillus cereus), gram-negative bacteria (Escherichia coli), and fungi (Candida albicans). Citral-loaded NLCs were spherically shaped nanosized (74.8 nm) particles with narrow size distribution, high EE% (99.84%), and appropriate physical stability during 90 days of storage period. FTIR spectra indicated the interaction between citral and formulation ingredients, which justified the obtained high EE% value. The MIC and MBC values of citral-loaded NLCs were lower than those of citral emulsion for all microorganisms. NLCs formulation showed remarkable capability of encapsulating essential oil and increasing antimicrobial properties to offer effective preservation in food industry.

show abstract

Biological hierarchically structured porous materials (Bio-HSPMs) for biomedical applications

et al. 2018

View full text Add to dashboard Cite

Modern progress and future challenges in nanocarriers for probe applications

Cited by 12 publications

References 166 publications

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Improvement of citral antimicrobial activity by incorporation into nanostructured lipid carriers: A potential application in food stuffs as a natural preservative

Biological hierarchically structured porous materials (Bio-HSPMs) for biomedical applications

Contact Info

Product

Resources

About