The article is dedicated to affective disorders developing in patients with primary painful bladder syndrome. The causes of their development and influence on the quality of patients’ life are considered. An overview of the etiopathogenic links between anxiety and depressive disorders and bladder pain is presented. it should be noted that common comorbidity with depressive and anxiety disorders is a risk factor for the unfavorable course and chronicity of pain conditions that requires to involve a psychotherapist or psychiatrist for examination and treatment of patients with primary painful bladder syndrome, and, if the somatoform nature of primary painful bladder syndrome is found, for prescribing relevant drug and non-drug treatment.