Modern Strategy for Identification of Congenital Heart Defects in the Neonatal Period

Kardasevic, Mediha; Jovanovic, Ida; Samardžić, Jelica Predojević

doi:10.5455/medarh.2016.70.384-388

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Congenital heart defects (CHD) are one of the most common congenital malformation and fatal birth defects in newborns, with over a quarter will develop seriously to a term called critical congenital heart defect. 1,2 According to the latest report of birth defects prevention and treatment in China, CHD has become the leading causes of the incidence of perinatal mortality since 2005. 3 The longterm survival rates of CHD have increased greatly ascribed to recent progresses made in interventional therapies, surgical procedure and clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: A multicenter case-control study on non-genetic risk factors in infants with congenital heart disease

W¹,

Deng²,

Huang³

et al. 2019

Preprint

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Background: The incidence of congenital heart disease (CHD) is growing at a rapid speed worldwide, which due to changes of both environmental and lifestyle exposures. This study aimed to explore how the non-genetic risk factors of maternal and perinatal conditions influenced onset of CHD in infants.Methods: Infants with congenital heart disease diagnosed by echocardiography from May 2012 to December 2013 were recruited as positive cases, while healthy individuals without congenital heart disease recruited at the same period were regarded as controls. The general situation of parents and the exposure to environmental factors during perinatal period in the case group and the control group were investigated by questionnaires.Results: A total of424 questionnaires of infants with congenital heart disease and 362 healthy controls were finally collected. We analyzed the risk factors during perinatal period of their mothers showed that their mothers took drugs in early pregnancy (odds ratio [OR]=4.41, 95 % confidence interval [CI]:2.41-6.73), viral infection (OR = 2.97, 95% CI: 1.62-5.73), house decoration (OR = 1.82, 95% CI: 1.43-3.75), hair dyeing and scalding (OR = 2.24, 95% CI:1.46-4.05), parents' exposures to work environment pollution (OR = 2.77, 95% CI: 2.03-5.38) were independent risk factors for cardiovascular malformations. With the increase of exposure factors, the risk of congenital heart disease increased significantly. When pregnant women were exposed to three or more risk factors at the same time, the risk of infants with congenital heart disease in was 17.24 times higher than that of single-factor exposure.Conclusions: Together, the incidence of CHD in infants is correlated with the exposure to perinatal risk factors.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: A multicenter case-control study on non-genetic risk factors in infants with congenital heart disease

W¹,

Deng²,

Huang³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Завдяки лабораторним можливостям у клінічній медицині, зокрема, розширенню спектра генетичних досліджень, стала можливою діагностика синдромальних форм ВВС, обумовлених мікроструктурними перебудовами хромосом і генними мутаціями. Дослідження останніх років свідчать, що однією з причин виникнення ВВС є варіації числа копій ДНК (CNV), які забезпечують структурну варіабельність геному і можуть бути як патогенними, так і нейтральними варіаціями [21].…”

Section: вступunclassified

Congenital heart diseases: frequency, causes, predictors of placental and fetal disorders

Galagan,

Lakatosh

2023

MPU

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Today, cardiovascular disease remains one of the main causes of morbidity, mortality and early disability in the population. Congenital heart diseases (CHD) is a leading cause of morbidity and mortality (up to 30%) and is one of the most severe conditions - multiple congenital malformations in children. Purpose - to analyze the literature data on the frequency of CHD, their causes, characteristics of the functioning of the fetoplacental system, and the importance of placental factors as markers of placental-fetal disorders to improve the effectiveness of prenatal diagnosis of heart defects and provide specialized medical care to pregnant women. A brief review of markers of early placental abnormalities and the development of heart defects, such as placental growth factor (PIGF), soluble form of fms-like tyrosine kinase-1 (sFlt-1), placental lactogen, and others, is provided. Given the significant proportion of fetoplacental insufficiency and CHD as the cause of perinatal losses, it is advisable to search for both genetic and morphological factors of their occurrence, which will improve prenatal diagnosis and the level of specialized care for pregnant women and children. Conclusions. The provided review of the literature indicated the possible causes of the occurrence of CHD, highlighted the relevance of the problem, which is primarily associated with a significant frequency of cardiovascular pathology and violations of the relationship and functioning of the fetoplacental system. Among the causes of congenital heart defects, multifactorial pathology has the greatest specific weight, the solution of the problem of diagnosis of which requires the combined action of obstetric-gynecological, cardiology, medical-genetic and pathomorphological services. Determination of placental factors PlGF and sFlt-1 in the blood can be recommended as criteria for prenatal diagnosis of defects of the cardiovascular system. No conflict of interests was declared by the authors.

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“…Similarly, molecular biomarkers too have shown considerable promise for use in prenatal diagnosis of CHD [ 150 , 151 , 152 ]. In addition to the above, detection of CHD neonates include clinical examinations, such as for congestive heart failure, a rhythm disturbance or heart murmur, cyanosis, and measurement of transcutaneous oxygen saturation [ 153 , 154 ]. Neonatal diagnosis has shown to be successful in detecting CHD and predicting outcomes [ 155 ].…”

Section: Diagnosis Of Chdmentioning

confidence: 99%

Insights into Cardiovascular Defects and Cardiac Epigenome in the Context of COVID-19

Sarkar

Sen

2022

Epigenomes

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Although few in number, studies on epigenome of the heart of COVID-19 patients show that epigenetic signatures such as DNA methylation are significantly altered, leading to changes in expression of several genes. It contributes to pathogenic cardiac phenotypes of COVID-19, e.g., low heart rate, myocardial edema, and myofibrillar disarray. DNA methylation studies reveal changes which likely contribute to cardiac disease through unknown mechanisms. The incidence of severe COVID-19 disease, including hospitalization, requiring respiratory support, morbidity, and mortality, is disproportionately higher in individuals with co-morbidities. This poses unprecedented strains on the global healthcare system. While their underlying conditions make patients more susceptible to severe COVID-19 disease, strained healthcare systems, lack of adequate support, or sedentary lifestyles from ongoing lockdowns have proved detrimental to their underlying health conditions, thus pushing them to severe risk of congenital heart disease (CHD) itself. Prophylactic vaccines against COVID-19 have ushered new hope for CHD. A common connection between COVID-19 and CHD is SARS-CoV-2’s host receptor ACE2, because ACE2 regulates and protects organs, including the heart, in various ways. ACE2 is a common therapeutic target against cardiovascular disease and COVID-19 which damages organs. Hence, this review explores the above regarding CHDs, cardiovascular damage, and cardiac epigenetics, in COVID-19 patients.

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Modern Strategy for Identification of Congenital Heart Defects in the Neonatal Period

Cited by 5 publications

References 28 publications

WITHDRAWN: A multicenter case-control study on non-genetic risk factors in infants with congenital heart disease

WITHDRAWN: A multicenter case-control study on non-genetic risk factors in infants with congenital heart disease

Congenital heart diseases: frequency, causes, predictors of placental and fetal disorders

Insights into Cardiovascular Defects and Cardiac Epigenome in the Context of COVID-19

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