The aim of the study was to carry out comparative analysis of effects observed in subjects exposed to light and music stimulation controlled by their own brain and heart biopotentials (closed-loop method) or biopotentials of another person. Materials and Methods. Volunteers under stress participated in two experiments in pairs. In the first experiment, light and music stimulation effects formed in each subject in a pair on the basis of their own brain and heart biopotentials, while in the second experiment, they formed on the basis of biopotentials of the other subject. Results. Both types of exposure caused reducing the tension of the regulatory systems in the body, reducing stress levels and improving the emotional state due to the mechanisms of multisensory integration and neuroplasticity. A significant increase in the power of the main EEG rhythms, accompanied by significant positive changes in psychological testing results and positive emotional responses to stimulation was observed only during light and music stimulation controlled by the subjects' own brain and heart biopotentials. These data are attributable to the integration of perception and processing of interoceptive signals significant for humans into the resonance mechanisms of the central nervous system, providing normalization of functional state due to stimulation. Conclusion. The data obtained can be used for developing the effective methods of personalized light and music stimulation aimed at timely elimination of functional disorders and returning the human body to homeostasis.