Modern Treatment Trends and Outcomes of Pulmonary Embolism With and Without Hemodynamic Significance

Mullan, Clancy; Newman, Joshua; Geib, M.; Pichert, Matthew D.; Saffarzadeh, Areo; Hartman, Alan R.; Lima, Brian

doi:10.1016/j.athoracsur.2020.02.041

Cited by 10 publications

(15 citation statements)

References 33 publications

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“…Regarding the use of systemic thrombolysis, we observed that this procedure was used in 5.5% of patients hospitalized with PE, slightly higher than what was found in the US, where according to the NIS from 2011 to 2014, among the 1,283,063 hospitalizations with PE, systemic thrombolysis use increased from 2.1% to 3.3% ( p < 0.001 for trend) [ 33 ]. A study conducted in another European country reported figures similar to ours [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Type 2 Diabetes Is a Risk Factor for Suffering and for in-Hospital Mortality with Pulmonary Embolism. A Population-Based Study in Spain (2016–2018)

Jiménez-García

Albaladejo-Vicente

Hernández‐Barrera

et al. 2020

IJERPH

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(1) Background: The relationship between type 2 diabetes (T2DM) and pulmonary embolism (PE) has not been well stablished so far. We aim to analyze incidence, clinical conditions and in-hospital mortality (IHM) according to the presence of T2DM among patients hospitalized for suffering from PE. The factors associated with IHM were identified. (2) Methods: Patients aged ≥40 years hospitalized for PE from 2016 to 2018 included in the Spanish National Health System Hospital Discharge Database were analyzed. Dependent variables included incidence, IHM and length of hospital stay. Independent variables were age, sex, diagnosed comorbidities, thrombolytic therapy and inferior vena cava filter placement. Poisson and logistic regression models were constructed for multivariable analysis. (3) Results: Of the 47,190 hospitalizations for PE recorded, 16.52% had T2DM. Adjusted incidence of PE was higher among T2DM women (IRR 1.83; 95% CI: 1.58–1.96) and men (IRR 1.22; 95% CI: 1.18–1.27) than among non-diabetic subjects. Crude IHM in T2DM patients with PE was similar in both sexes but higher than in non-diabetic patients. Among T2DM patients with PE, risk factors for IHM included older age, comorbidity, atrial fibrillation and massive PE. Obesity was associated with lower IHM. Suffering T2DM was a risk of IHM (OR 1.15; 95% CI 1.05–1.26) after PE. (4) Conclusions: The incidence of PE is higher in T2DM men and women than in non-diabetic patients. T2DM was a risk factor for IHM after PE.

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Section: Discussionmentioning

confidence: 99%

Type 2 Diabetes Is a Risk Factor for Suffering and for in-Hospital Mortality with Pulmonary Embolism. A Population-Based Study in Spain (2016–2018)

Jiménez-García

Albaladejo-Vicente

Hernández‐Barrera

et al. 2020

IJERPH

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“…Catheter-directed thrombolysis is when low-dose fibrinolytic agents are directly injected into the pulmonary artery at a slow infusion rate, often over the course of 12-24 h. The theoretical advantage of this technique is that the fibrinolytic infusion is at the site of thrombosis and a lower dose of fibrinolytics can be given despite longer exposure. There is conflicting evidence as to whether catheter-directed thrombolysis has less bleeding risk compared to systemic thrombolysis [30,31].…”

Section: Catheter-directed Therapiesmentioning

confidence: 99%

Advanced management of intermediate-high risk pulmonary embolism

2021

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“…Catheter-directed thrombolysis (CDT) is an emerging therapeutic option in the treatment of PE, with the intention of decreasing the dosage of the thrombolytic agent via local delivery. 6 The mentioned dose reduction is presumed to translate into less bleeding. 6 In the present case report, we describe 2 patients with acute PE, complicated by IHE during CDT.…”

Section: Introductionmentioning

confidence: 99%

“…6 The mentioned dose reduction is presumed to translate into less bleeding. 6 In the present case report, we describe 2 patients with acute PE, complicated by IHE during CDT.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Intramural Esophageal Hematoma Secondary to Thrombolysis in the Setting of Pulmonary Embolism

Taghavyan

Mashayekh

Pouraliakbar

et al. 2021

Vasc Endovascular Surg

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Intramural hematoma of the esophagus (IHE) represents a rare condition on the spectrum of esophageal injuries. The most common symptoms are hematemesis, epigastric pain or retrosternal chest pains, odynophagia, and dysphagia. Early recognition of IHE is important as it may mimic other diseases such as myocardial infarction, pulmonary embolism, Mallory–Weiss tears, Boerhaave’s syndrome, ruptured aortic aneurysms, and aortic dissection. Computed tomography is the preferred investigation method, and treatment is usually conservative. We herein present 2 cases of IHE associated with catheter-directed thrombolysis in the setting of pulmonary embolism.

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Modern Treatment Trends and Outcomes of Pulmonary Embolism With and Without Hemodynamic Significance

Cited by 10 publications

References 33 publications

Type 2 Diabetes Is a Risk Factor for Suffering and for in-Hospital Mortality with Pulmonary Embolism. A Population-Based Study in Spain (2016–2018)

Type 2 Diabetes Is a Risk Factor for Suffering and for in-Hospital Mortality with Pulmonary Embolism. A Population-Based Study in Spain (2016–2018)

Advanced management of intermediate-high risk pulmonary embolism

Spontaneous Intramural Esophageal Hematoma Secondary to Thrombolysis in the Setting of Pulmonary Embolism

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