This article describes the design of a centrifuge for the separation of fat from meat–bone slurry to produce fat-extracted animal feed. The characteristics of the main components of the equipment and the principle of its operation were presented. The productivity of the centrifuge depending on duration and speed of rotation was determined. Data were provided for different drum speeds (1000, 1500, 2000, 2500 rpm) and centrifugation durations (5, 7, 10 and 15 min), with the yield (output) of defatted slurry measured as a percentage. Among the various conditions tested, the maximum yield of slurry was observed when the drum was rotated at 2000 rpm for 5 min, with a yield of 68.97%, while the lowest yield was observed when the drum was rotated at 1000 rpm for 15 min, with a yield of 55%. On the basis of modeling, a physical model including centrifugal separation with simultaneous centrifugal filtration was presented in the form of a system of differential, algebraic, and criterion equations.