Modern views on urogenital mycoplasma infection

Fofanova, I Yu; Юрьевна, Фофанова Ирина; Prilepskaya, V N; Николаевна, Прилепская Вера

doi:10.26442/2079-5831_16.2.4-8

Cited by 3 publications

(3 citation statements)

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“…Отсутствие различий в содержании Тлимфоцитов у обеих групп животных можно объяснить тем, что микоплазмы обладают широкой антигенной вариабельностью, а фагоцитоз при микоплазмозе часто незавершенный, что в итоге приводит к разрыву кооперации между макрофагами и Т-лимфоцитами [4].…”

Section: результаты и обсуждениеunclassified

“…Полимеразная цепная реакция (ПЦР) в режиме реального времени и с электрофоретической детекцией широко применяется в ветеринарных лабораториях. Благодаря своей высокой чувстви-тельности, ПЦР позволяет выявить возбудителя даже при минимальном его содержании, особенно это актуально при бессимптомном течении инфекционного процесса [2,3,4,8].…”

Section: Introductionunclassified

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Indicators of cellular immunity in cows with genital Mycoplasmosis

Vasiliev

2022

jour

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Urogenital mycoplasmosis is currently widespread in livestock farms both in our country and abroad. Unfortunately, today we have little data on the pathogenesis of this disease, and in particular on the state of the immune system of cows with genital mycoplasmosis. We have carried out a comparative study of indicators of cellular immunity in healthy cows and cows with genital mycoplasmosis. The study was carried out on pregnant cows. In healthy and mycoplasma-infected cows, the relative and absolute content of lymphocyte subpopulations was determined. It has been established that with genital mycoplasmosis in cows there is a significant decrease in the number of leukocytes and a decrease in the relative and absolute content of B-lymphocytes. Thus, infected animals develop a moderate immunodeficiency state due to prolonged exposure to mycoplasma metabolites, which inhibit the proliferative activity of immunocompetent cells. These changes should be taken into account when developing treatment regimens for genital mycoplasmosis.

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Section: результаты и обсуждениеunclassified

Section: Introductionunclassified

Indicators of cellular immunity in cows with genital Mycoplasmosis

Vasiliev

2022

jour

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“…чем выше концентрация гениталь-ных микоплазм, тем чаще наблюдаются преждевременное излитие околоплодных вод, преждевременные роды, рождение детей с низкой массой тела, послеродовый эндометрит, увеличивается частота вертикальной передачи инфекции [15,16]. Участие урогенитальных микоплазм в развитии большого числа патологических состояний в гинекологии и акушерстве диктует необходимость своевременной диагностики и, при необходимости, этиопатогенетической терапии [5].…”

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Influence of the Massiveness of Infection of the Genital Tract With Urogenital Mycoplasmas on the Course and Outcomes of Pregnancy in Women of the Amur Region

Vlasova¹,

Suprun²,

Suprun³

et al. 2018

Bulletin Physiology and Pathology of Respiration

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In order to study the role of urogenital mycoplasmas on the course and outcomes of pregnancy, depending on its quantitative assessment using the real-time PCR, 159 rural women of the Amur region were examined. Infection with Ureaplasma species (spp.) was revealed in 51.2% of cases, among them in clinically significant concentrations (in the form of monoinfection or in combination with other opportunistic microorganisms) it was found in 39.0% of cases. Mycoplasma hominis in clinically significant concentration was determined in 15.1% of pregnant women, among them in 8.8% it was in combination with Ureaplasma spp. The effects of massive infection of the genital tract with urogenital mycoplasmas on the course and outcomes of pregnancy were evaluated in 85 patients. Four groups of pregnant women were formed according to the results of clinical and laboratory examinations. Group 1 (n=19) included pregnant women with convenional normocenosis (Lactobaccilus spp. ≥106 GE/mL, Ureaplasma spp ≥104 GE/mL); group 2 (n=23) included patients with identified urogenital mycoplasma (Ureaplasma spp and Mycoplasma hominis) in clinically significant concentrations in combination with other opportunistic microorganisms (Streptococcus agalactiae, Enterobacteriaceae, Staphylococcus spp., Gardnerella vaginalis, Bacteroides spp. and others). Pregnant women with vaginal dysbiosis (Lactobacillus sp. ≤106 GE/mL) and the absence of urogenital mycoplasmas were included in group 3 (n=13). The control group included 30 pregnant women with normal vaginal flora and the absence of urogenital mycoplasmas. The exclusion criteria were the identification of unconditional pathogens (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium) and the activation of herpesvirus infections (HSV and CMV). As a result of the study, pregnant women in the main groups were 4.7-7 times more often to be diagnosed with fetal growth retardation syndrome; 2.0–3.2 times more often to have placental insufficiency compared with subjects in the control group. Premature birth in women of group 1 was registered 3.3 times more often than in the control group. In the same group, there was a tendency to increase the number of pregnant women with a long anhydrous period and premature discharge of amniotic fluid.

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Capabilities of combined peptide drugs in the correction of male infertility (literature review)

Prokopiev

Abdrakhmanov

2021

Consilium Medicum

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Acute and chronic urogenital infections are associated with male infertility. Besides "traditional" sexually transmitted infections, there is a significant increase in inflammatory diseases of reproductive system caused by opportunistic pathogens. Studies show that sperm fertility is influenced by direct exposure to sexually transmitted infections, as well as dysfunction of the blood-testicular barrier, leading to autoimmune infertility. In a number of clinical trials, Prostatilen AC was shown to have benefitial effects on the ejaculate.

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Modern views on urogenital mycoplasma infection

Cited by 3 publications

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Indicators of cellular immunity in cows with genital Mycoplasmosis

Indicators of cellular immunity in cows with genital Mycoplasmosis

Influence of the Massiveness of Infection of the Genital Tract With Urogenital Mycoplasmas on the Course and Outcomes of Pregnancy in Women of the Amur Region

Capabilities of combined peptide drugs in the correction of male infertility (literature review)

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