Moderne Therapie der stabilen koronaren Herzkrankheit: Der Stellenwert                der koronaren Revaskularisation

Heiniger, P.S; Holy, Erik W.; Maier, Willibald; Nietlispach, Fabiàn; Ruschitzka, Frank; Stähli, Barbara E.

doi:10.1024/1661-8157/a003216

Cited by 2 publications

(1 citation statement)

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“…For this research, CAE was defined as the diameter of the dilated artery exceeding 1.5 times the diameter of the adjacent normal segment [10]. CHD (control group 1) was defined as ≥50% stenosis of ≥1 major coronary artery [11]. The degree of coronary artery stenosis was <20% in the relatively-normal-coronary group (control group 2).…”

Section: Methodsmentioning

confidence: 99%

Peripheral blood soluble elastin and elastase as auxiliary diagnostic indicators for coronary artery ectasia

Liu¹,

Sheng²,

Liang³

et al. 2021

Turk J Med Sci

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Background/aim: Damage to elastin fibres in coronary media might lead to coronary artery ectasia (CAE). This study evaluated whether CAE can be distinguished by detecting circulating soluble elastin (s-elastin), which is a degradation product of elastin fibres, and elastase, which is the main enzyme of elastin fibres.Materials and methods: Fifty-eight patients with CAE, 58 with coronary heart disease (CHD) and 61 with relatively normal coronary arteries, were included. Circulating s-elastin and elastase were measured, and receiver operating characteristic curves were used to demonstrate their respective optimal cut-off values for predicting CAE.Results: The concentrations of s-elastin and elastase were higher in the CAE group than in the CHD and relatively-normal-coronary groups. Their cut-off values for screening of CAE were 13.148 ng/mL and 25.549 ng/mL, respectively; for sensitivity of CAE were 0.690 and 0.773, respectively; and for specificity of CAE were 0.862 and 0.571, respectively. A combination of s-elastin and elastase in series (one of the two higher than its cut-off value) had a better sensitivity for screening for CAE, whereas their combination in parallel (both higher than their cut-off values) had a better specificity. Conclusion:Circulating s-elastin and elastase are promising biomarkers for assisting in CAE diagnosis.

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Section: Methodsmentioning

confidence: 99%