The article presents the experience of Kazan National Research Technical University named after A.N. Tupolev—KAI (the former HEI’s name is KAI—Kazan Aviation Institute) in the implementation of the policy of career guidance of students and prospective students. The purpose of the article is to share the original KAI practices in the field of career guidance of prospective students, as well as to reveal the essence of the solutions incorporated into the key career guidance activities of the university. Original solutions are described, including: installation of the first supersonic passenger aircraft TU-144 on the territory of the KAI campus; the first scientific-practical conference of young aviators “Aviation of the Future: Trends, Challenges and Opportunities”, dedicated to the 50th anniversary of the first flight of the TU-144 aircraft; creation of an educational complex “Technopolis” for the development of children’s engineering creativity; an online course for schoolchildren during the university’s career guidance campaign “KAI Online School CYBER.TECH”; extended day groups for schoolchildren; the project for the training of new generation of engineers “Wings of Rostec” implemented with the support of the State Corporation Rostec, and some other projects. The factors of entry and retention of personnel in professional communities are identified and systematized, taking into account the professional life cycle of a specialist. It has been identified that in modern conditions, career guidance activities have begun to significantly influence the updating of educational content and modes of study at the university, which is confirmed by the presence of interactive and online KAI events. The university forms and develops an environment favorable for self-determination and self-realization of all participants in the educational process, while covering a variety of target groups.