Modes of action associated with uranium induced adverse effects in bone function and development

Arzuaga, Xabier; Gehlhaus, Martin; Strong, J.H.

doi:10.1016/j.toxlet.2015.05.006

Cited by 30 publications

(13 citation statements)

References 88 publications

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“…Biomarkers of adverse biological effects have been investigated in several animal models. For instance specific cardiovascular markers associated with cardiovascular effects resulting from 137 Cs exposure [278,279] and kidney and brain markers after uranium exposure (total calculated dose of 0.15 mGy on the kidney) have been identified [280][281][282][283]. Biomarkers of adaptive response were observed in certain conditions of chronic exposure of mice to 137 Cs (absorbed dose 5 to 150-150 mGy) where inflammatory cytokines decrease [279] or chronic exposure of rats to uranium where renal glutathione levels increase dose-dependently (absorbed dose to the kidney 0.15 mGy to 5mGy) [284].…”

Section: New Biomarkers Of Effectsmentioning

confidence: 99%

Ionizing radiation biomarkers in epidemiological studies – An update

Hall

Jeggo

West

et al. 2017

Mutation Research/Reviews in Mutation Research

128

105

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Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of <100mSv and dose rates of <10mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30-60mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk. Further progress requires integration of biomarkers or bioassays of individual exposure, effects and susceptibility to IR. The European DoReMi (Low Dose Research towards Multidisciplinary Integration) consortium previously reviewed biomarkers for potential use in IR epidemiological studies. Given the increased mechanistic understanding of responses to low dose radiation the current review provides an update covering technical advances and recent studies. A key issue identified is deciding which biomarkers to progress. A roadmap is provided for biomarker development from discovery to implementation and used to summarise the current status of proposed biomarkers for epidemiological studies. Most potential biomarkers remain at the discovery stage and for some there is sufficient evidence that further development is not warranted. One biomarker identified in the final stages of development and as a priority for further research is radiation specific mRNA transcript profiles.

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Section: New Biomarkers Of Effectsmentioning

confidence: 99%

Ionizing radiation biomarkers in epidemiological studies – An update

Hall

Jeggo

West

et al. 2017

Mutation Research/Reviews in Mutation Research

128

105

View full text Add to dashboard Cite

show abstract

“…Furthermore, uranium may alter the metabolism of vitamin D and affect normal bone functions and growth indirectly. Uranium-induced alterations in vitamin D production and levels may modify mineral homeostasis, affect bone maintenance, and reduce bone growth in the elderly [ 42 ].…”

Section: Entry Routes and Health Effectsmentioning

confidence: 99%

The toxicological mechanisms and detoxification of depleted uranium exposure

Yue

Wang

et al. 2018

Environ Health Prev Med

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Depleted uranium (DU) has been widely applied in industrial and military activities, and is often obtained from producing fuel for nuclear reactors. DU may be released into the environment, polluting air, soil, and water, and is considered to exert both radiological and chemical toxicity. In humans and animals, DU can induce multiple health effects, such as renal tubular necrosis and bone malignancies. This review summarizes the known information on DU’s routes of entry, mechanisms of toxicity, and health effects. In addition, we survey the chelating agents used in ameliorating DU toxicity.

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“…It can affect bone development and maintenance, especially in young individuals. The accumulation mechanism is mainly the substitution of U for calcium in the osseous tissue [ 19 ]. Most U is excreted rapidly from the body via urine and feces, but about 1−1.5% is assumed to be adsorbed in the gastrointestinal tract in adults.…”

Section: Introductionmentioning

confidence: 99%

“…Most U is excreted rapidly from the body via urine and feces, but about 1−1.5% is assumed to be adsorbed in the gastrointestinal tract in adults. In bones, U retention has a half-live between 70 and 200 days, 80−90% of deposited U leaves the body after 1.5 years [ 17 , 19 , 20 ]. As an alpha particle emitter, adsorbed radioactive U may also lead to DNA damage and therefore carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Drinking Water Uranium and Potential Health Effects in the German Federal State of Bavaria

Banning

Benfer

2017

IJERPH

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Mainly due to its nephrotoxic and osteotoxic potential, uranium (U) increasingly finds itself in the spotlight of environmental and health-related research. Germany decided on a binding U guideline value in drinking water of 10 µg/L, valid since 2011. It is yet widely unknown if and how public health was affected by elevated U concentrations before that. In this ecological study we summarized available drinking water U data for the German federal state of Bavaria (703 analyses in total for 553 different municipalities) at county level (for 76 out of 96 Bavarian counties, representing about 83% of Bavaria’s and about 13% of Germany’s total population) in terms of mean and maximum U concentration. Bavaria is known to regionally exhibit mainly geogenically elevated groundwater U with a maximum value of 40 µg/L in the database used here. Public health data were obtained from federal statistical authorities at county resolution. These included incidence rates of diagnosed diseases suspected to be potentially associated with chronic U uptake, e.g., diseases of the skeleton, the liver or the thyroid as well as tumor and genito-urinary diseases. The datasets were analyzed for interrelations and mutual spatial occurrence using statistical approaches and GIS as well as odds ratios and relative risks calculations. Weak but significant positive associations between maximum U concentrations and aggregated ICD-10 diagnose groups for growths/tumors as well as liver diseases were observed, elevated incidence rates of thyroid diseases seem to occur where mean drinking water U concentrations exceed 2 µg/L. Here, we discuss obtained results and their implications for potential impacts of hydrochemistry on public health in southeast Germany.

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Modes of action associated with uranium induced adverse effects in bone function and development

Cited by 30 publications

References 88 publications

Ionizing radiation biomarkers in epidemiological studies – An update

Ionizing radiation biomarkers in epidemiological studies – An update

The toxicological mechanisms and detoxification of depleted uranium exposure

Drinking Water Uranium and Potential Health Effects in the German Federal State of Bavaria

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