Modifcation of anthelmintic drugs by nanotechnology (review)

Varlamova, A. I.; Архипов, И А; Халиков, С. С.; Arisov, M. V.

doi:10.31016/1998-8435-2022-16-2-213-229

Ross. parazitol. ž..

2022

DOI: 10.31016/1998-8435-2022-16-2-213-229

|View full text |Cite

Modifcation of anthelmintic drugs by nanotechnology (review)

A. I. Varlamova

И А Архипов

С. С. Халиков

et al.

Abstract: The purpose of the research is to analyze and summarize the literature data and the results of our own studies on the use of drug delivery systems and methods for increasing the solubility and efcacy of anthelmintic drugs.Helminthoses are one of the most important problems in veterinary medicine and animal husbandry, not only due to the pathological eﬀects, but also due to the spread of anthelmintic resistance. Since the development of new anthelmintic substances takes many years and investment, some strategie… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Study of subchronic oral toxicity of Altric-Extra drug in laboratory animals

Golovin,

Abramov,

Balyshev

et al. 2023

Ross. parazitol. ž..

View full text Add to dashboard Cite

The purpose of the research is to determine main toxicological parameters in repeated intragastric administration of Altric-Extra for veterinary use to laboratory outbred rats.Materials and methods. White outbred rats were used as a test system in the study. The experiment used clinical, toxicological, biochemical and morphological research methods.Results and discussion. Altric-Extra doses of 325 and 650 mg/kg were toxic for the laboratory animals. When administered daily intragastrically to the rats in the above doses, the drug had a negative effect on the functional status of the hemopoietic organs, and excretory and digestive systems. The main target organ for this drug is the thymus. Functional disorders in the above organs and systems are irreversible as evidenced by the post-mortem examination, general blood analysis, and biochemical blood test obtained 10 days after the drug administration was completed.

show abstract

Study of subchronic oral toxicity of Altric-Extra drug in laboratory animals

Golovin,

Abramov,

Balyshev

et al. 2023

Ross. parazitol. ž..

View full text Add to dashboard Cite

show abstract

Evaluation of some toxicological parameters of Oxantel-, Pyrantel- and Praziquantel-based anthelmintic in tablet formulation for dogs and cats

Arisova

2024

Ross. parazitol. ž..

View full text Add to dashboard Cite

The purpose of the research is to evaluate some toxicological parameters of a new combined anthelmintic based on oxantel pamoate, pyrantel pamoate and praziquantel in tablet formulation for dogs and cats.Materials and methods. The studies used 70 outbred male rats and 50 outbred male mice. Acute oral toxicity was studied in male mice and male rats weighing 14–16 and 160–180 g, respectively. The subchronic toxicity study with the drug administered repeatedly, orally for 14 days was conducted on male rats weighing 180–200 g. The study monitored the laboratory animals’ overall health status, behavior and possible death, and any intoxication symptoms were recorded. All studies were performed using conventional techniques for experimental (preclinical) studies of new pharmacological substances using the guidelines edited by R. U. Khabriev (2005) and A. I. Mironov et al. (2012). Additionally, the experiments assessed clinical toxicological, biochemical, and morphological parameters of the laboratory animals.Results and discussion. In evaluation of the drug acute toxicity in the male mice and the female rats, the LD50 exceeded the dose of 6000 mg/kg; the animals showed no signs of intoxication during the entire study. Thus, the drug was classified as substance hazard category 4. Doses 600, 300 and 120 mg/kg of the drug had no negative effect on the organism of the laboratory animals in the subchronic experiment on the male rats; the doses were ineffective (safe). The threshold or toxic dose could not be determined.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Modifcation of anthelmintic drugs by nanotechnology (review)

Cited by 2 publications

References 69 publications

Study of subchronic oral toxicity of Altric-Extra drug in laboratory animals

Study of subchronic oral toxicity of Altric-Extra drug in laboratory animals

Evaluation of some toxicological parameters of Oxantel-, Pyrantel- and Praziquantel-based anthelmintic in tablet formulation for dogs and cats

Contact Info

Product

Resources

About