Modifiable Lifestyle Factors in Dementia: A Systematic Review of Longitudinal Observational Cohort Studies

Marco, Luigi Yuri Di; Marzo, Alberto; Muñoz-Ruiz, Miguel Ángel; Ikram, M. Arfan; Kivipelto, Miia; Ruefenacht, Daniel; Venneri, Annalena; Soininen, Hilkka; Wanke, Isabel; Ventikos, Yiannis; Frangi, Alejandro F.

doi:10.3233/jad-132225

Cited by 148 publications

(138 citation statements)

References 107 publications

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“…Systematic reviews have reported that in mixed older populations, mostly without MCI, incident AD has been predicted by higher homocysteine levels, lower educational attainment, and decreased physical activity 14 . Conflicting results have been reported for the association between dementia and other putative risk factors (smoking) and protective factors (mild-to-moderate alcohol consumption, dietary antioxidants, Mediterranean diet, and living with others) 16 . Neuropsychiatric symptoms predict MCI in cognitively normal populations 15 .…”

Section: Introductionmentioning

confidence: 83%

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Cooper¹,

Sommerlad²,

Lyketsos³

et al. 2015

AJP

449

314

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Objectives: Public health campaigns encouraging early help-seeking have increased rates of Mild Cognitive Impairment (MCI) diagnosis in Western countries, but we know little about how to treat or prognosticate dementia outcomes in persons with MCI. Method: We searched electronic databases and references for longitudinal studies reporting potentially modifiable risk factors for incident dementia after MCI. Two authors independently evaluated study quality using a checklist. We meta-analysed findings from three or more studies. Results: We identified 76 eligible papers. Diabetes and prediabetes increased risk of conversion from amnestic MCI (aMCI) to Alzheimer's Dementia (AD); risk in treated versus untreated diabetes was lower in one study. Diabetes was also associated with increased risk of conversion from any type or non-amnestic MCI to all cause dementia. Metabolic syndrome and pre-diabetes predicted all cause dementia in people with aMCI and any type MCI respectively. Mediterranean diet decreased risk of conversion from aMCI to AD. Presence of neuropsychiatric symptoms or lower serum folate levels predicted conversion from any type MCI to all cause dementia, but less formal education did not. Depressive symptoms predicted conversion from any type MCI to dementia in epidemiological, but not clinical studies. Conclusions: Diabetes increased the risk of conversion to dementia. Other prognostic factors that are potentially manageable are pre-diabetes and the metabolic syndrome, neuropsychiatric symptoms and low dietary folate. Dietary interventions and interventions to reduce neuropsychiatric symptoms including depression, which increase conversion risk to dementia, may decrease incident dementia.

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Section: Introductionmentioning

confidence: 83%

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Cooper¹,

Sommerlad²,

Lyketsos³

et al. 2015

AJP

449

314

View full text Add to dashboard Cite

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“…Impaired health literacy, poorer self-management, and adverse health behaviors, such as smoking, have been linked to low income and could explain this association. From epidemiologic data, smoking appears to be a risk factor for both diabetes and dementia (38)(39)(40); however, levels of current smoking are comparable between the populations with and without diabetes and fall significantly over age 65 years (23,41). Whether prior smoking predicts dementia (or significantly differed across groups) is unclear.…”

Section: Discussionmentioning

confidence: 99%

Risk of Dementia in Seniors With Newly Diagnosed Diabetes: A Population-Based Study

et al. 2015

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OBJECTIVETo study whether diabetes onset in late life is a risk factor for dementia. RESEARCH DESIGN AND METHODSWe conducted a population-based matched cohort study using provincial health data from Ontario, Canada. Seniors with (n = 225,045) and without newly diagnosed diabetes (n = 668,070) between April 1995 and March 2007 were followed until March 2012 for a new diagnosis of dementia. Cox proportional hazards modeling was used to compare the risk of dementia between groups after adjusting for baseline cardiovascular disease, chronic kidney disease (CKD), hypertension, and other risk factors. RESULTSOver this period, we observed 169,114 new cases of dementia. Individuals with diabetes had a modestly higher incidence of dementia (2.68 vs. 2.62 per 100 person-years) than those without diabetes. In the fully adjusted Cox model, the risk of dementia was 16% higher among our subgroup with diabetes (hazard ratio [HR] 1.16 [95% CI 1.15-1.18]). Adjusted HRs for dementia were 1.20 (95% CI 1.17-1.22) and 1.14 (95% CI 1.12-1.16) among men and women, respectively. Among seniors with diabetes, the risk of dementia was greatest in those with prior cerebrovascular disease (HR 2.03; 95% CI 1.88-2.19), peripheral vascular disease (HR 1.47; 95% CI 1.19-1.82), and CKD (HR 1.44; 95% CI 1.38-1.51), and those with one or more hospital visits for hypoglycemia (HR 1.73; 95% CI 1.62-1.84). CONCLUSIONSIn this population-based study, newly diagnosed diabetes was associated with a 16% increase in the risk of dementia among seniors. Preexisting vascular disease and severe hypoglycemia were the greatest risk factors for dementia in seniors with diabetes.

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“…O hábito alimentar pode exercer um significante papel no desenvolvimento da doença de Alzheimer e de outras demências (Di Marco, et al, 2014).…”

Section: Insuficiência Cognitivaunclassified

“…Isso reforça a importância das medidas de prevenção para as demências, e vários estudos sugerem um possível papel da alimentação e do estilo de vida na gênese de doenças como Alzheimer e demência vascular (Di Marco, et al, 2014).…”

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Estilo de vida e intervenções não farmacológicas no tratamento e na prevenção das síndromes geriátricas: uma revisão integrativa

et al. 2017

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As grandes síndromes geriátricas — insuficiência cognitiva, instabilidade postural, incontinência urinária, iatrogenia e imobilidade — estão associadas ao declínio da capacidade funcional de importante parcela da população idosa. Esta revisão faz uma compilação e análise de estudos que abordam a importância do estilo de vida, da alimentação, de exercícios físicos, e de outras medidas não farmacológicas, na prevenção e no tratamento dos chamados “gigantes da geriatria”, condições de alta prevalência e morbidade na população idosa.

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Modifiable Lifestyle Factors in Dementia: A Systematic Review of Longitudinal Observational Cohort Studies

Cited by 148 publications

References 107 publications

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Risk of Dementia in Seniors With Newly Diagnosed Diabetes: A Population-Based Study

Estilo de vida e intervenções não farmacológicas no tratamento e na prevenção das síndromes geriátricas: uma revisão integrativa

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