Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk?

Derby, Carol A.; Mohr, Beth A.; Goldstein, Irwin; Feldman, Henry A.; Johannes, Catherine B.; McKinlay, John B.

doi:10.1016/s0090-4295(00)00614-2

Cited by 495 publications

(335 citation statements)

References 26 publications

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“…An observation by Derby et al (32) confirmed the influence of men’s physical activity on ED and stressed that it remains the only factor whose positive modification, even in mid-life, may reduce the risk of ED. Leisure-time physical activity also figures into physical capacity; both these factors, according to an observation by Agostini et al (33), are related to ED.…”

Section: Discussionmentioning

confidence: 94%

Heart rate recovery, cardiac rehabilitation and erectile dysfunction in males with ischaemic heart disease

Kałka

Domagała²,

Rusiecki³

et al. 2015

Anatol J Cardiol

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Objective:Heart rate recovery (HRR) is a recognised marker used in clinical practice for assessing the risk of sudden cardiac death. Physical exercise leads to an improvement in HRR and has a proven beneficial effect on erection quality (EQ) related to the activity of the autonomic nervous system in men with ischaemic heart disease (IHD). This paper evaluates the relationship between HRR and EQ in patients with IHD and erectile dysfunction (ED) who underwent cardiac rehabilitation.Methods:The main analysis was based on the Mann–Whitney U test, Wilcoxon signed-rank test, Spearman correlation coefficient, Pearson’s chi-square test, chi-square test, with the Yates correction and (if possible) parametric tests were used. This prospective, non-randomised intervention study included 124 men with IHD and ED [International Index of Erectile Function (IIEF-5) scores of ≤21]. Of these, 89 patients underwent a 6-month cardiac rehabilitation phase III programme, whereas 35 did not. The results of the participants’ total IIEF-5 scores and their HRR, demographic and clinical data were analysed.Results:The results of the 89 rehabilitated patients (mean age: 60.44±9.29 years) and 35 controls (mean age: 61.43±8.81 years) were analysed. In the rehabilitated patients, the mean baseline IIEF-5 score was 13.15±5.76 (95% CI: 11.93–14.36) and HRR was 16.49±7.68/min (95% CI: 14.88–18.11). After cardiac rehabilitation, the parameters of ED and HRR improved significantly and were significantly higher than those of the controls; the mean IIEF-5 score of the rehabilitated group increased to 15.36±6.51 (95% CI: 13.99–16.73), while HRR increased to 21.40±7.25/min (95% CI: 19.88–22.93). A significant correlation was found between ∆HRR and ∆EQ (r=0.409791) as a result of the 6-month cardiac training programmeConclusion:Cardiac rehabilitation assessed by HRR has a sizable effect on autonomic balance in patients with IHD and ED, which plays a significant role in the mechanism of erection improvement.

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Section: Discussionmentioning

confidence: 94%

Heart rate recovery, cardiac rehabilitation and erectile dysfunction in males with ischaemic heart disease

Kałka

Domagała²,

Rusiecki³

et al. 2015

Anatol J Cardiol

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“…17 Questions 1-5 and 15 of the IIEF constitute the erectile function domain, which is used to assess global erectile function. Scoring the IIEF domain of erectile function allowed the classification of each patient as follows: absent of ED (26)(27)(28)(29)(30), mild ED (17)(18)(19)(20)(21)(22)(23)(24)(25), moderate ED (11)(12)(13)(14)(15)(16) and severe ED (0-10).…”

Section: Methodsmentioning

confidence: 99%

Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity

Chu

et al. 2009

Int J Impot Res

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We determined the association between the severity of erectile dysfunction (ED) and traditional cardiovascular risk factors, including metabolic syndrome (MS). A total of 141 ED patients were divided into three groups on the basis of ED severity, which was determined using the International Index of Erectile Function (IIEF) scores. The prevalence of MS among the ED patients was 32.6%. Significantly lower IIEF scores were noted in patients with MS than in patients without MS (7.6±6.4 vs 11.6±7.4, P ¼ 0.003). As assessed by the anthropometric indices of body mass index, waist circumference and waist-to-hip ratio, obesity was detected in 58.9, 54.6 and 32.6% of the patients, respectively. Of the 141 patients, 39 had mild, 24 had moderate and 78 had severe ED. Statistically significant differences were noted among the different ED severity groups with regard to the presence of hypertension, systolic blood pressure, presence of MS and number of MS components. Multivariate analysis showed that the odds ratio for high-low-density lipoprotein (LDL) cholesterol level in moderate and severe ED, determined with reference to mild ED, were 9.346 and 6.452, respectively. The presence of MS, number of MS components, and certain traditional cardiovascular risk factors, particularly high-LDL cholesterol level and hypertension, may influence the severity of ED.

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“…Intervention on modifiable health behaviors, especially reducing body weight and increasing physical activity, may in theory be a safe strategy to reduce the risk of both erectile and endothelial dysfunction. In the Massachusetts Male Aging Study, for example, Derby et al 68 found that men who were overweight at baseline were at an increased risk of developing ED regardless of whether they lost weight during the follow-up records. Moreover, epidemiological evidence suggests that physical activity is associated with a 30% lower risk of ED.…”

Section: Lifestyle and Sexual Functionmentioning

confidence: 99%

Obesity and sexual dysfunction, male and female

et al. 2008

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Obesity has become a worldwide public health problem of epidemic proportions, as it may decrease life expectancy by 7 years at the age of 40 years: excess bodyweight is now the sixth most important risk factor contributing to the overall burden of disease worldwide. Overweight and obesity may increase the risk of erectile dysfunction (ED) by 30-90% as compared with normal weight subjects. On the other hand, subjects with ED tend to be heavier and with a greater waist than subjects without ED, and also are more likely to be hypertensive and hypercholesterolemic. The metabolic syndrome, characterized by a clustering of risk factors associated with insulin resistance and abdominal obesity, associates with ED. Moreover, women with the metabolic syndrome have an increased prevalence of sexual dysfunctions as compared with matched control women. Lifestyle changes aimed at reducing body weight and increasing physical activity induce amelioration of both erectile and endothelial functions in obese men. Moreover, preliminary evidence suggests that a Mediterranean-style diet might be effective in ameliorating sexual function in women with the metabolic syndrome. Lifestyle changes, mainly focussing on regular physical activity and a healthy diet, are effective and safe ways to reduce cardiovascular diseases and premature mortality in all population groups; they may also prevent and treat sexual dysfunctions in both sexes.

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Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk?

Cited by 495 publications

References 26 publications

Heart rate recovery, cardiac rehabilitation and erectile dysfunction in males with ischaemic heart disease

Heart rate recovery, cardiac rehabilitation and erectile dysfunction in males with ischaemic heart disease

Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity

Obesity and sexual dysfunction, male and female

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