Modificaciones epigenéticas en neurología: alteraciones en la metilación del ADN en la esclerosis múltiple

Zulet, M. Iridoy; Fontes, L. Pulido; Blanco, T. Ayuso; Bescos, F. Lacruz; Mendioroz, Maite

doi:10.1016/j.nrl.2015.03.011

Cited by 15 publications

(2 citation statements)

References 42 publications

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“…The ratio of SAM to SAH determines whether methyltransferase reactions can occur. The higher the ratio, the greater the methylation potential [ 64 ]; in contrast, if the ratio of SAM to SAH is low, methyltransferase reactions do not occur and coronavirus RNA is not methylated [ 65 ]. As a result, the virus cannot replicate and the viral genomes present in the cell are susceptible to degradation [ 57 ].…”

Section: Amino Acid Metabolismmentioning

confidence: 99%

Amino Acid Metabolism in Leukocytes Showing In Vitro IgG Memory from SARS-CoV2-Infected Patients

Fanelli,

Lelli,

Rinalducci

et al. 2024

Diseases

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The immune response to infectious diseases is directly influenced by metabolic activities. COVID-19 is a disease that affects the entire body and can significantly impact cellular metabolism. Recent studies have focused their analysis on the potential connections between post-infection stages of SARS-CoV2 and different metabolic pathways. The spike S1 antigen was found to have in vitro IgG antibody memory for PBMCs when obtaining PBMC cultures 60–90 days post infection, and a significant increase in S-adenosyl homocysteine, sarcosine, and arginine was detected by mass spectrometric analysis. The involvement of these metabolites in physiological recovery from viral infections and immune activity is well documented, and they may provide a new and simple method to better comprehend the impact of SARS-CoV2 on leukocytes. Moreover, there was a significant change in the metabolism of the tryptophan and urea cycle pathways in leukocytes with IgG memory. With these data, together with results from the literature, it seems that leukocyte metabolism is reprogrammed after viral pathogenesis by activating certain amino acid pathways, which may be related to protective immunity against SARS-CoV2.

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Section: Amino Acid Metabolismmentioning

confidence: 99%

Amino Acid Metabolism in Leukocytes Showing In Vitro IgG Memory from SARS-CoV2-Infected Patients

Fanelli,

Lelli,

Rinalducci

et al. 2024

Diseases

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“…Interestingly, hypomethylation of PADI2 has also been observed in PBMC from MS patients [91]. Additionally, the reduction of methylation has been found in T cell IL-17A promoter, which results in an increased IL-17, and subsequently leads to the inflammation of the central nervous system [92,93].…”

Section: Chronic Inflammatory Disordersmentioning

confidence: 99%

Trained Innate Immunity Not Always Amicable

Włodarczyk

Druszczyńska

Fol

2019

IJMS

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The concept of “trained innate immunity” is understood as the ability of innate immune cells to remember invading agents and to respond nonspecifically to reinfection with increased strength. Trained immunity is orchestrated by epigenetic modifications leading to changes in gene expression and cell physiology. Although this phenomenon was originally seen mainly as a beneficial effect, since it confers broad immunological protection, enhanced immune response of reprogrammed innate immune cells might result in the development or persistence of chronic metabolic, autoimmune or neuroinfalmmatory disorders. This paper overviews several examples where the induction of trained immunity may be essential in the development of diseases characterized by flawed innate immune response.

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Peripheral nerve injury and myelination: Potential therapeutic strategies

Modrak

Talukder

Gurgenashvili

et al. 2019

J of Neuroscience Research

153

118

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Traumatic peripheral nerve injury represents a major clinical and public health problem that often leads to significant functional impairment and permanent disability. Despite modern diagnostic procedures and advanced microsurgical techniques, functional recovery after peripheral nerve repair is often unsatisfactory. Therefore, there is an unmet need for new therapeutic or adjunctive strategies to promote the functional recovery in nerve injury patients. In contrast to the central nervous system, Schwann cells in the peripheral nervous system play a pivotal role in several aspects of nerve repair such as degeneration, remyelination, and axonal growth. Several non‐surgical approaches, including pharmacological, electrical, cell‐based, and laser therapies, have been employed to promote myelination and enhance functional recovery after peripheral nerve injury. This review will succinctly discuss the potential therapeutic strategies in the context of myelination following peripheral neurotrauma.

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Modificaciones epigenéticas en neurología: alteraciones en la metilación del ADN en la esclerosis múltiple

Abstract: Knowledge of epigenetic modifications involved in the pathogenesis of MS, opens a new avenue of research for identification of potential biomarkers, as well as finding new therapeutic targets.

Cited by 15 publications

References 42 publications

Amino Acid Metabolism in Leukocytes Showing In Vitro IgG Memory from SARS-CoV2-Infected Patients

Amino Acid Metabolism in Leukocytes Showing In Vitro IgG Memory from SARS-CoV2-Infected Patients

Trained Innate Immunity Not Always Amicable

Peripheral nerve injury and myelination: Potential therapeutic strategies

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