Modification and testing of a pneumatic dispensing device for controlled delivery of injectable materials

Abstract

This VF injection system shows promise for development to enhance human phonosurgery by increasing injection control and precision.

Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty

“…Additionally, devices have been created to use a controlled pneumatic force to push injectate smoothly through the needle. 8 CaHA and CMC are 2 of the most commonly used FDAapproved products for IL. In an effort to understand the changes that these 2 products undergo with heat and shearing, their rheologic properties were carefully studied and found to be consistent with findings of Sundaram et al 9 In addition, 2 important findings were noted from the current study.…”

Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges

“… 75 In addition, coating the inner surface of the needle/catheter with proteins may reduce cell adhesion to the device. 76 In addition to possible adherence to device materials, cells may encounter residual trace amounts of manufacturing agents that could induce apoptosis or undesired differentiation. The use of hydrophilic and siliconised coatings on internal walls of the cannula has also been suggested to decrease friction between the needle and tissue in vivo.…”

Quantification of injection force mechanics during injection laryngoplasty

“…With smaller forces than 100N recorded for all systems evaluated in this study, the accumulation of pressure and poor feedback from injection resistance confound hand‐operated injection even with smaller force values because visualization under the microscope blinds the user to the injection hand and disrupts stability necessary to ensure proper placement of the material to avoid tissue scarring or suboptimal outcomes . Due to these considerations, there has been recent interest in the development of assistive pneumatic dispensing devices . To that end, the findings of this study have the potential to improve the feedback controls on such devices and enhance their function to actively sense material injection by providing an understanding of needle orientation and material behavior‐based changes in injection forces.…”

“…16 Due to these considerations, there has been recent interest in the development of assistive pneumatic dispensing devices. 17 To that end, the findings of this study have the potential to improve the feedback controls on such devices and enhance their function to actively sense material injection by providing an understanding of needle orientation and material behavior-based changes in injection forces.…”