Modification by dexamethasone of radiation response of in vitro cultured cells

Dexamethasone-Induced Enhancement of Resistance to Ionizing Radiation and Chemotherapeutic Agents in Human Tumor Cells

“…Several additional reports, however, have also been published describing radioprotective effects of dexamethasone in a number of malignant cell lines established from solid murine tumors [2,[14][15][16]19]. Together, these reports suggest that corticosteroid-induced radioresistance is probably not a rare phenomenon in solid mammalian tumor cells.…”

“…Corticosteroid-induced enhancement in radioresistance had previously been reported to occur in another human cervical carcinoma line [19], whereas no inducible radioprotection was observed in a human bladder carcinoma line [15], a human breast cancer cell line [2], nor in fetal [15] or normal human diploid skin fibroblasts [2], nor in 2 human glioblastoma cell lines [15]. Several additional reports, however, have also been published describing radioprotective effects of dexamethasone in a number of malignant cell lines established from solid murine tumors [2,[14][15][16]19].…”

Dexamethasone-induced radioresistance occurring independent of human papilloma virus gene expression in cervical carcinoma cells

“…However, dexamethasone-induced radioresistance does not occur in all human cell types. Dexamethasone did not confer radioresistance in breast carcinoma cell line MCF-7 nor in normal diploid fibroblast strain AG 1522 [2], nor in glioblastoma cell lines Ul18 MG and U251 MG [15].…”