Modification by Exercise Training of Activity and Enzyme Expression of Hepatic Branched-Chain .ALPHA.-Ketoacid Dehydrogenase Complex in Streptozotocin-Induced Diabetic Rats.

Li, Zhihao; Murakami, Taro; Nakai, Norihiro; Nagasaki, Masaru; Obayashi, Mariko; Xu, Ming; Sato, Juichi; Oshida, Yoshiharu; Sato, Yuzo; Shimomura, Yoshiharu

doi:10.3177/jnsv.47.345

Cited by 13 publications

(12 citation statements)

References 27 publications

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“…However, the BCKDH complex activity was not changed in CLF, suggesting that muscular BCAA catabolism is increased only in ALF. Such activation of the muscular BCKDH complex with high serum BCAA concentrations was also observed in rats stressed with exercise [18] and with diabetes [25,33]. Although muscular BCKA catabolism was promoted, it did not appear to be sufficient to compensate for the decreased hepatic BCKA oxidation observed in the rats.…”

Section: Discussionmentioning

confidence: 65%

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Effects of liver failure on branched-chain α-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure

Honda

Fukuda

Nakano

et al. 2004

Journal of Hepatology

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Section: Discussionmentioning

confidence: 65%

“…The E1a and E2 components were easily visualized. However, the signal for E1b was too weak for accurate quantification [25,26]. Immunoreactive bands were quantified with the use of NIH Image (Version 1.61) software.…”

Section: Western Blottingmentioning

confidence: 99%

Effects of liver failure on branched-chain α-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure

Honda

Fukuda

Nakano

et al. 2004

Journal of Hepatology

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“…Another explanation might be possible because Shimomura et al (24,25) reported that exercise training modulates the gene expression of BCKDC and increases the BCKDC activity. Namely, it is that the difference of urinary excretion of branched 2-oxo acids is not dependent on the functional biomarker of B-group vitamins but it is dependent on the levels of physical activity.…”

Section: Discussionmentioning

confidence: 99%

Urinary Branched-Chain 2-Oxo Acids as a Biomarker for Function of B-Group Vitamins in Humans

Shibata

Sakamoto

2016

J Nutr Sci Vitaminol

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SummaryTo find a functional biomarker of B-group vitamins, we collected 24-h urine samples from young Japanese women who lived in the community (n529) to measure branched-chain 2-oxo acids such as 2-oxo-3-methylbutanoic acid, 2-oxo-3-methylpentanoic acid, and 2-oxo-4-methylpentanoic acid because B-group vitamins are involved in the catabolism of branched-chain amino acids. The relationships between each pair of the three urinary 2-oxo acids were very high (2-oxo-3-methylbutanoic acid and 2-oxo-3-methylpentanoic acid, p,0.001; 2-oxo-3-methylbutanoic acid and 2-oxo-4-methylpentanoic acid, p,0.001; 2-oxo-3-methylpentanoic acid and 2-oxo-4-methylpentanoic acid, p,0.001). The participants were divided into three groups using the upper (n510), middle (n59), and lower tertiles (n510) based on the urinary excretion amounts of the sum of the three branchedchain 2-oxo acids. The administration of capsules containing the daily necessary amounts of B-group vitamins led to a decrease in the urinary excretion of the sum of the three types of branched-chain 2-oxo acids in participants belonging to the upper tertile. A similar phenomenon was observed in the middle tertile, but not in the lower tertile. Intakes of B-group vitamins and the urinary excretion amounts of B-group vitamins were not observed to be significantly different among the upper, middle, and lower tertiles. These results indicate that some young Japanese women need much higher levels of B-group vitamins than the Dietary Reference Intakes for Japanese. Thus, urinary branched-chain 2-oxo acids are useful functional biomarkers for B-group vitamins in humans.

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“…Such glycogen sparing is particularly critical for resistance to exercise-induced hypoglycemia with aging, because hepatic capacity for gluconeogenesis and liver glycogen stores decline with age (Donovan and Sumida, 1997). In rats with streptozocin-induced diabetes, training also reduced hepatic catabolism of branched-chain amino acids, in association with the suppression of diabetes-induced branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex expression in the liver (Li et al, 2001). Secretion of growth hormone in response to its hypothalamic releasing factor is especially enhanced by resistance exercise.…”

Section: Introductionmentioning

confidence: 98%

Effect of exercise on hepatic gene expression in rats: a microarray analysis

Aoi¹,

Ichiishi²,

Sakamoto³

et al. 2004

Life Sciences

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Modification by Exercise Training of Activity and Enzyme Expression of Hepatic Branched-Chain .ALPHA.-Ketoacid Dehydrogenase Complex in Streptozotocin-Induced Diabetic Rats.

Cited by 13 publications

References 27 publications

Effects of liver failure on branched-chain α-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure

Effects of liver failure on branched-chain α-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure

Urinary Branched-Chain 2-Oxo Acids as a Biomarker for Function of B-Group Vitamins in Humans

Effect of exercise on hepatic gene expression in rats: a microarray analysis

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