Modification by focused ultrasound pulses of electrically evoked responses from an in vitro hippocampal preparation

Rinaldi, Patricia C.; Jones, Joie P.; Reines, F.; Price, LeRoy R.

doi:10.1016/0006-8993(91)90711-4

Cited by 87 publications

(70 citation statements)

References 15 publications

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“…Structural changes suggest accompanying functional changes. Neuronal tissue responses to insonification have been reported peripherally [6,7] and centrally [8,9,10], although the underlying mechanism (whether radiation force directly, radiation force via extracellular and intracellular streaming, cavitation, or heating) has not yet been determined.…”

Section: Introductionmentioning

confidence: 97%

Hippocampal culture stimulus with 4-megahertz ultrasound

Muratore¹,

LaManna²,

Lamprecht³

et al. 2012

AIP Conference Proceedings

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Among current modalities, ultrasound uniquely offers both millisecond and millimeter accuracy in noninvasively stimulating brain tissue. In addition, by sweeping the ultrasound beam within the refractory period of the neuronal tissue, ultrasonic neuromodulation can be adapted to target extended or multiply connected regions with quasi-simultaneity. Towards the development of this safe brain stimulus technique, the response of rat hippocampal cultures to ultrasound was investigated. Hippocampal slices, 0.4-mm thick, were obtained from 8-day old Sprague Dawley rats and cultured for 6 days. The in vitro cultures were exposed to multiple 100-ms 4.04-MHz ultrasound pulses from a 42-mm diameter, 90-mm spherical cap transducer. Peak pressure ranged from 0 through about 77 kPa. Responses in the form of electrical potentials from a sixty channel electrode array were digitized and recorded. The DG and CA1 regions of the hippocampus exhibited similar ultrasonically-evoked field potentials.

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Section: Introductionmentioning

confidence: 97%

Hippocampal culture stimulus with 4-megahertz ultrasound

Muratore¹,

LaManna²,

Lamprecht³

et al. 2012

AIP Conference Proceedings

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“…However, in these years, the study of functional effects of ultrasound was developed in some foreign laboratories [70][71][72][73]. It was shown that single pulses of focused ultrasound can significantly modify the excit ability of the myelinated nervous fibers of the sciatic nerve of a frog (in vitro) during 40-50 ms after the ter mination of the pulse [70,71].…”

Section: Studies In the 1990-2000smentioning

confidence: 99%

“…Focused ultrasound was also used to modify evoked potentials and the functioning of local nerve circuits in the mammalian brain [72,73]. The samples of rat hip pocampal preparations in vitro were used as an object of studies.…”

Section: Studies In the 1990-2000smentioning

confidence: 99%

Focused ultrasound as a tool to input sensory information to humans (Review)

Гаврилов

Tsirulnikov

2012

Acoust. Phys.

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This review is devoted to the analysis of studies and implementations related to the use of focused ultrasound for functional effects on neuroreceptor structures. Special attention was paid to the stimulation of neuroreceptor structures in order to input sensory information to humans. This branch of medical and phys iological acoustics appeared in Russia in the early 1970s and was being efficiently developed up to the late 1980s. Then, due to lack of financial support, only individual researchers remained at this field and, as a result, we have no full fledged theoretical research and practical implementations in this area yet. Many promising possibilities of using functional effects of focused ultrasound in medicine and physiology have remained unimplemented for a long time. However, new interesting ideas and approaches have appeared in recent years. Very recently, very questionable projects have been reported related to the use of ultrasound for targeted functional effects on the human brain performed in some laboratories. In this review, the stages of the development of scientific research devoted to the functional effects of focused ultrasound are described. By activating the neuroreceptor structures of the skin by means pulses of focused ultrasound, one can cause all the sensations perceived by human beings through the skin in everyday life, such as tactile sensations, ther mal (heat and cold), tickling, itching, and various types of pain. Stimulation of the ear labyrinth of humans with normal hearing using amplitude modulated ultrasound causes auditory sensations corresponding to an audio modulating signal (pure tones, music, speech, etc.). Activation of neuroreceptor structures by means of focused ultrasound is used for the diagnosis of various neurological and skin diseases, as well as hearing dis orders. It has been shown that the activation is related to the mechanical action of ultrasound, for example, by the radiation force, as well as to the direct action of ultrasonic vibrations on nerve fibers. The action of the radiation force is promising for the realization of the possibility of blind and even deaf and blind people to perceive text information on a display using tactile sensations caused by ultrasound. Very different methods of using ultrasound for local stimulation of neuroreceptor structures are discussed in this review. Among them are practical methods that have been already tested in a clinic, as well as pretending to be sensational methods that are hardly feasible in the foreseeable future.

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“…Multiple in vitro and in vivo studies have demonstrated the ability of focused ultrasound to both reversibly and irreversibly block nerve conduction 102-105 . Other US parameters may in fact activate neural tissue, both peripherally and in the central nervous system 106 .…”

Section: Future Neurological Applicationsmentioning

confidence: 99%

Magnetic Resonance–Guided Focused Ultrasound Surgery

Medel¹,

Monteith²,

Elias³

et al. 2012

Neurosurgery

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Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) represents a novel combination of technologies that is actively being realized as a non-invasive therapeutic tool for a myriad of conditions. These applications are reviewed with a focus on neurological utilization. A combined search of Pubmed and Medline was performed to identify the key events and current status of MRgFUS, with a focus on neurological applications. MRgFUS signifies a potentially ideal device for the treatment of neurological diseases. As it is nearly real-time, it allows monitored provision of treatment location and energy deposition, is noninvasive, thereby limiting or eliminating disruption of normal tissue, provides focal delivery of therapeutic agents, enhances radiation delivery, and permits modulation of neural function. Multiple clinical applications are currently in clinical use and many more are under active preclinical investigation. The therapeutic potential of MRgFUS is expanding rapidly. Although clinically in its infancy, preclinical and early phase I clinical trials in neurosurgery suggest a promising future for MRgFUS. Further investigation is necessary to define its true potential and impact.

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Modification by focused ultrasound pulses of electrically evoked responses from an in vitro hippocampal preparation

Cited by 87 publications

References 15 publications

Hippocampal culture stimulus with 4-megahertz ultrasound

Hippocampal culture stimulus with 4-megahertz ultrasound

Focused ultrasound as a tool to input sensory information to humans (Review)

Magnetic Resonance–Guided Focused Ultrasound Surgery

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