Modification by Insulin of the Distribution of Two Model Amino Acids in the Rat<sup>1</sup>

Sanders, Robert B.; Riggs, Thomas R.

doi:10.1210/endo-80-1-29

Cited by 41 publications

(10 citation statements)

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“…Insulin has been found to enhance amino acid transport into the tissues of animals and this hormone is effective in vitro [1,19,20] as well as in vivo [18]. Since secondary secretion of insulin might occur in response to epinephrine-induced hyperglycemia and since Chambers el al.…”

Section: Discussionmentioning

confidence: 99%

“…Experiments were carried out in the manner reported earlier in our studies with insulin [18] and epinephrine [17]. Immature female Sprague-Dawley-Holtzman rats were used in all experiments.…”

Section: Methodsmentioning

confidence: 99%

“…The general experimental plan was the same as that reported earlier [17,18]. Either 7.7 /¿moles of *' IC-ACPC or 9.7 /¿moles of " C-AIB per kilogram of body weight was injected (i.p.)…”

Section: Methodsmentioning

confidence: 99%

“…When mannoheptulose was used, it was injected 3 h before the rats were killed. Other details of the procedure and calculations have been given [18]. Values presented in the tables arc means ± standard errors of the means.…”

Section: Methodsmentioning

confidence: 99%

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Action of Epinephrine on the Distribution of Two Model Amino Acids in the Diabetic Rat

Sanders¹,

Jacob²

1971

Pharmacology

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The injection of epinephrine (1.0 mg/kg) into alloxan-diabetic, fasted rats depressed the serum concentration of previously administered α-aminoisobutyric acid (AIB) and 1-aminocyclopentanecarboxylic acid (ACPC) within 2 h and simultaneously increased the concentration of these amino acids in the liver. The increase of ACPC and AIB concentrations in the liver following epinephrine injection was nearly 3 times as great in the alloxan-diabetic rats as in normal intact rats. The levels of the two amino acids in skeletal muscle, heart, and diaphragm of the alloxanized rats were unchanged following epinephrine injection, but the distribution ratios in these tissues were raised because the serum concentration decreased 20%.Further studies were carried out employing rats that were treated 1 h before epinephrine injection, with mannoheptulose, a compound which blocks insulin release. The concentration of ACPC and AIB in the serum 2 h after epinephrine injection were lowered. At the same time the concentrations of ACPC in liver and heart were raised, as was the concentration of AIB in heart. The levels of the two amino acids in skeletal muscle and diaphragm were unaltered. However, distribution ratios were raised in the four tissues. These results demonstrate that epinephrine enhances AIB and ACPC transport into the tissues of the insulin-deficient rats in vivo and suggest that epinephrine-stimulated amino acid transport is not due indirectly to insulin.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The general experimental plan was the same as that reported earlier [17,18]. Either 7.7 /¿moles of *' IC-ACPC or 9.7 /¿moles of " C-AIB per kilogram of body weight was injected (i.p.)…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Action of Epinephrine on the Distribution of Two Model Amino Acids in the Diabetic Rat

Sanders¹,

Jacob²

1971

Pharmacology

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“…To measure amino acid uptake, we used radioisotopic a-aminoisobutyric acid ([ 3H ] -AIB), an amino acid that is neither metabolized nor incorporated into protein [24] and is mainly transported by the Nat-dependent system A [25,26]. The results showed that AIB uptake by the tumor tissue was high and that the changes in AIB uptake by the muscle and liver of tumor-bearing rats were similar to those seen in starvation and sepsis and after injury.…”

mentioning

confidence: 99%

Distribution of a non-metabolizable amino acid in different tissues of tumor-bearing rats in cachexia.

Takehara

James

Fischer

1990

J. Clin. Biochem. Nutr.

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Effect of Insulin on Amino Acid Uptake and Protein Turnover in Skeletal Muscle From Septic Rats

Hasselgren¹,

Warner²,

James³

et al. 1987

Arch Surg

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Modification by Insulin of the Distribution of Two Model Amino Acids in the Rat¹

Cited by 41 publications

References 0 publications

Action of Epinephrine on the Distribution of Two Model Amino Acids in the Diabetic Rat

Action of Epinephrine on the Distribution of Two Model Amino Acids in the Diabetic Rat

Distribution of a non-metabolizable amino acid in different tissues of tumor-bearing rats in cachexia.

Effect of Insulin on Amino Acid Uptake and Protein Turnover in Skeletal Muscle From Septic Rats

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Modification by Insulin of the Distribution of Two Model Amino Acids in the Rat1

Cited by 41 publications

References 0 publications

Action of Epinephrine on the Distribution of Two Model Amino Acids in the Diabetic Rat

Action of Epinephrine on the Distribution of Two Model Amino Acids in the Diabetic Rat

Distribution of a non-metabolizable amino acid in different tissues of tumor-bearing rats in cachexia.

Effect of Insulin on Amino Acid Uptake and Protein Turnover in Skeletal Muscle From Septic Rats

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Modification by Insulin of the Distribution of Two Model Amino Acids in the Rat¹