Modification by Temperature of the Response of Isolated Aorta to Stimulatory Agents and Transmural Stimulation

Toda, Noboru; Hojo, Masashi; Sakae, Koichiro

doi:10.1159/000158090

Cited by 11 publications

(10 citation statements)

References 8 publications

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“…10~6 M), blood vessels contract most strong ly at temperatures between 20 and 35 °C, weakly at temperatures below 20, and weakly also at temperatures above 35 °C. This pattern has been reported for peripheral arteries [5,10,12,18] and central arteries [20], though peripheral veins show a differ ent pattern in which contractile strength is increased by cooling [17].…”

supporting

confidence: 77%

“…The fall in arterial responsiveness to NE that occurs during further cooling may result at least in part from nonadrenergic factors, as some investigators have reported that re sponses to the depolarizing action of high-K+ solutions decline in parallel to the decline in responses to NE [ 17,20]. However, though it is possible that reduced a-adrenoceptor af finity may be involved in inhibiting contrac tile responses at temperatures below 20 °C, no studies have measured adrenoceptor af finity at low temperatures.…”

mentioning

confidence: 99%

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Effect of Temperature on Alpha-Adrenoceptor Affinity and Contractility of Rabbit Ear Blood Vessels

Roberts

Chilgren²,

Zygmunt³

1989

J Vasc Res

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We have studied contractile responses to norepinephrine (NE) and K⁺ of isolated rabbit ear arteries and veins in an effort to determine how α -adrenoceptor affinity and smooth muscle contractility affect responsiveness at different temperatures. Arteries have predominantly α₁-adrenoceptors and veins have predominantly receptors of the α₂-type. We obtained dose-response curves to NE at 9, 16, 23, 30, 37 and 42 °C in the absence and presence of the irreversible α -adrenoceptor blocker phenoxybenzamine (POB). In both vessels, affinity of the α -adrenoceptors was determined by comparing equieffective doses of NE before and after blockade of the receptors. In other experiments, we obtained contractions to 80 mMKCl at the same temperatures. Affinity of the ear arterial α₁-receptors was maximal at 23 °C, while affinity of ear venous α₂-receptors increased linearly with cooling to 9 °C. Responses to K⁺ in both vessels decreased with cooling. Taken together, the changes in receptor affinity and response to K⁺ may explain the shape of curves relating contractile strength to temperature.

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supporting

confidence: 77%

mentioning

confidence: 99%

Effect of Temperature on Alpha-Adrenoceptor Affinity and Contractility of Rabbit Ear Blood Vessels

Roberts

Chilgren²,

Zygmunt³

1989

J Vasc Res

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“…Cooling is known to increase vasoconstrictor tone and prolongs smooth muscle contraction. 6 Therefore, complete closure after cooling can be explained on the basis of increased vasomotor tone and prolonged contraction in the cases with no recordable pulsations. It is, however, more difficult to explain the pressure reduction after cooling, and here one has to think about a delayed opening after reduction of the finger tourniquet pressure.…”

Section: Discussionmentioning

confidence: 99%

Response of Digital Blood Pressure to Cold Provocation in Cases with Raynaud Phenomena

1981

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A new diagnostic test of the qualitative and quantitative evaluation of vasospastic disorders is described. It entails measurement of systolic digital artery pressure during successive cooling from 35-5 degrees C. In cases with vasospastic disorders with Raynaud phenomena a significant reduction of systolic blood pressure below 78% of control level is observed and in the most pronounced cases total cessation of flow occurs (critical closing). The test is also a quantitative measure of the degree of vasospasm since the pressure reduction correlates to the clinical degree of vasoconstriction.

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“…Toda et al (19) showed that the contractile response of rabbit aortas to vasoconstrictor drugs reached a maximum between 33 and 37°C.…”

mentioning

confidence: 99%

Thermomechanical behavior of human carotid arteries in the passive state

Guinea¹,

Atienza²,

Elices³

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

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Localized heating or cooling is expanding the clinical procedures used to treat cardiovascular diseases. Advantageous implementation and development of these methods are linked indissolubly to a deeper understanding of the arterial response to combined mechanical and thermal loads. Despite this, the basic thermomechanical behavior of human blood vessels still remains largely unknown, primarily due to the lack of appropriate experimental data. In this work, the influence of temperature on the passive behavior of human carotid arteries was studied in vitro by means of inflation tests. Eleven carotid segments were tested in the range 0 -200 mmHg at four different temperatures of 17, 27, 37, and 42°C. The results show that the combined change of temperature and stress has a dramatic effect on the dilatation coefficient of the arterial wall, which is shifted from negative to positive depending on the stress state, whereas the structural stiffness of the arterial wall does not change appreciably in the range of temperatures tested. blood vessels; inflation tests; thermal dilatation coefficient; mechanical properties; structural stiffness QUANTITATIVE KNOWLEDGE of the thermomechanical behavior of human arteries is fundamental for a better understanding of the physiology of the cardiovascular system and for the development of treatment methods and techniques for cardiovascular diseases, such as angioplasty, stent, or bypass surgery. Although much has been written on arterial mechanics (see Ref.9 and the references herein), thermomechanical experiments on human blood vessels are scarce, and in most cases only physiological temperatures (35-37°C) are considered. Nearly all the data available on the combined response of blood vessels to mechanical and thermal loading come from tests on mammalians such as rabbits, pigs, or dogs.The thermomechanical behavior of arteries, however, is not a secondary issue in cardiovascular research because many cardiac surgical procedures are performed at nonphysiological temperatures; coronary artery bypass surgeries are ordinarily performed in conditions of hypothermia (26 -31°C) (13), and hyperthermia over 50°C is routinely used in thermal balloon angioplasty (3,10,16,22).Still today, a lot of efforts are devoted to understanding the effects of changes in temperature on the final results of the treatments and the quality of life of the patients (13, 16). Also, the influence of temperature on vascular properties is important in situations like organ preservation, because modifications of temperature could affect intrarenal vasodilatation, bypass surgery, and extracorporeal circulation.In addition, thermomechanical experimental data are needed for the development of appropriate constitutive equations for the arterial wall (9, 18) implemented in numerical models, which are proving to be a useful tool for surgical procedures as well as for other clinical cardiovascular issues such as the assessment of plaque vulnerability (9).The first study on the effect of temperature on human blood vessels ...

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Modification by Temperature of the Response of Isolated Aorta to Stimulatory Agents and Transmural Stimulation

Cited by 11 publications

References 8 publications

Effect of Temperature on Alpha-Adrenoceptor Affinity and Contractility of Rabbit Ear Blood Vessels

Effect of Temperature on Alpha-Adrenoceptor Affinity and Contractility of Rabbit Ear Blood Vessels

Response of Digital Blood Pressure to Cold Provocation in Cases with Raynaud Phenomena

Thermomechanical behavior of human carotid arteries in the passive state

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