Modification of [2.2]paracyclophane through cobalt-catalyzed ortho-C–H allylation and acyloxylation

Abstract

It is nontrivial to access 4,5-sisubstituted [2.2]paracyclophanes by directed C–H functionalization, due to the steric hindrance. Here we reported the first cobalt-catalyzed C‒H functionalizaiton of [2,2]paracyclophanes assisted by 8-aminoquinoline directing...

Oxidative Alkenylation of (Hetero)aromatics with Unactivated Alkenes: Control of the Reaction Selectivity

“…Besides Maiti's group, similar cobalt catalyzed oxidative allylation of amino‐quinoline derived amides were also reported by Chatani, [63] Ackermann, [64] and Shi [65] in recent years (Scheme 23c~e). It is worth mentioning that Ackermann pioneered the initial cobalt‐catalyzed electrochemical C−H allylation in the biomass‐derived solvent γ ‐valerolactone (GVL).…”

Iridium(iii)-catalyzed one-pot synthesis of planar chiral emissive materials through C–H activation

“…Pioneering reports by the Bolm group 29 in 2012 and the Bräse group 30 in 2014 introduced the palladium-catalyzed ortho -C–H acetoxylation and C–H halogenation of [2.2]paracyclophane derivatives. Subsequently, the Shi group 31 reported cobalt-catalyzed ortho -C–H allylation and acyloxylation of [2.2]paracyclophane derivatives, further expanding the synthetic possibilities. These seminal works have unlocked avenues for the direct catalytic transformation of [2.2]paracyclophane into new functional molecules.…”