Modification of a nitrocellulose membrane with nanofibers for sensitivity enhancement in lateral flow test strips

Wang, Xue; Xue, Chao-Hua; Yang, Dong; She, Jia; Ding, Ya-Ru; Lei, Lei; Gao, Keyi; Jia, Tongtong

doi:10.1039/d1ra04369b

Cited by 16 publications

(8 citation statements)

References 50 publications

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“…The authors achieved an eight-fold enhancement in the LOD for human chorionic gonadotropin measurement compared to the conventional LFA [ 28 ]. Other published works in this field employed cellulose fibers as the sample pad, creating a wall before the test line region onto the nitrocellulose film, and the use of chitosan and nanofiber on nitrocellulose membrane [ 29 , 50 , 51 ]. All these approaches can slow the flow rate and modify the sensitivity of recognition from one to multiple folds in LFA.…”

Section: Assay Improvementmentioning

confidence: 99%

Lateral Flow Assay: A Summary of Recent Progress for Improving Assay Performance

Omidfar,

Riahi,

Kashanian

2023

Biosensors

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Lateral flow tests are one of the most important types of paper-based point-of-care (POCT) diagnostic tools. It shows great potential as an implement for improving the rapid screening and management of infections in global pandemics or other potential health disorders by using minimally expert staff in locations where no sophisticated laboratory services are accessible. They can detect different types of biomarkers in various biological samples and provide the results in a little time at a low price. An important challenge regarding conventional LFAs is increasing their sensitivity and specificity. There are two main approaches to increase sensitivity and specificity, including assay improvement and target enrichment. Assay improvement comprises the assay optimization and signal amplification techniques. In this study, a summarize of various sensitivity and specificity enhancement strategies with an objective evaluation are presented, such as detection element immobilization, capillary flow rate adjusting, label evolution, sample extraction and enrichment, etc. and also the key findings in improving the LFA performance and solving their limitations are discussed along with numerous examples.

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Section: Assay Improvementmentioning

confidence: 99%

Lateral Flow Assay: A Summary of Recent Progress for Improving Assay Performance

Omidfar,

Riahi,

Kashanian

2023

Biosensors

View full text Add to dashboard Cite

show abstract

“…[69][70][71] Second, they can be used in macroscopic flow-through systems. [72][73][74][75] Finally, EMs can be used as parts of LFA [76][77][78][79][80][81] or microfluidic devices. [82][83][84][85][86][87] The fundamental difference between these two options is the mechanism of liquid movement.…”

Section: Integration Of Electrospun Membranes Into Sensorsmentioning

confidence: 99%

Optical sensors based on electrospun membranes – principles, applications, and prospects for chemistry and biology

et al. 2022

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“…[7][8][9][10][11] Energetic polymer material is an important binder as well as energetic component, which has been widely used in propellants, explosives and pyrotechnics. [12][13][14][15][16] Recently, Laser ignition of energetic materials and propellants has gradually attracted the attention of researchers. [17,18] However, most of the energetic polymers, such as nitrocellulose (NC) and energetic thermoplastic elastomer (ETPE), show poor laser ignition and combustion efficiency due to their molecular constitution.…”

Section: Introductionmentioning

confidence: 99%

Tuning the micro‐structure, laser ignition, and isovolumetric burning performance of nitrocellulose propellant via incorporation of graphene oxide

et al. 2023

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Nanoscale recombination between carbon nanomaterials (CNs) and polymers has been proposed for a variety of industrial and scientific applications.Composite energetic materials consisting of CNs with novel laser ignition property and tunable combustion performance have attracted people's attention. Here, reported is the novel manufacturing process of uniform nitrocellulose (NC)/graphene oxide (GO) nanocomposite propellant and the microstructure, laser ignition and isovolumetric burning features of the propellants introduced by GO. The results of microstructure tests indicated that GO (0.25-2 wt%) was stripped and dispersed homogeneously and dense nanocomposite

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Modification of a nitrocellulose membrane with nanofibers for sensitivity enhancement in lateral flow test strips

Abstract: We constructed a new type of ICT strip by replacing the conventional nitrocellulose membrane with an electrospin-coated nitrocellulose (ENC) fibrous membrane, and the ICT strip could obtain an HCG detection limit of 0.22 mIU mL−1, and an LH detection limit of 0.36 mIU mL−1.

Cited by 16 publications

References 50 publications

Lateral Flow Assay: A Summary of Recent Progress for Improving Assay Performance

Lateral Flow Assay: A Summary of Recent Progress for Improving Assay Performance

Optical sensors based on electrospun membranes – principles, applications, and prospects for chemistry and biology

Tuning the micro‐structure, laser ignition, and isovolumetric burning performance of nitrocellulose propellant via incorporation of graphene oxide

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