Modification of acetaminophen crystals: influence of growth in aqueous solutions containing p-acetoxyacetanilide on crystal properties

Dissolution and mechanical behaviors of recrystallized carbamazepine from alcohol solution in the presence of additives

“…It is possible that the presence of some additives in the crystal growth medium may block the growth of the higher energy sites of the crystal surfaces, making them less available for active dissolution as suggested by Chow et al [37].…”

Investigations on Solid–Solid Phase Transformation of 5-Methyl-2-[(4-Methyl-2-Nitrophenyl)Amino]-3- Thiophenecarbonitrile

“…The change in free energy corresponds to a change in the thermodynamic activity. [24][25][26][27][28] An increase in free energy corresponds to an increase in the reactivity of the crystals because the defects act as high-energy sites and hence influence the chemical stability of the crystals. [29][30][31][32] For the transformation of 5-methyl-2-[(4-methyl-2nitro-phenyl)amino]-3-thiophenecarbonitrile of the dark-red form to the red form, it is suggested that a collection of particles will have a distribution of energies.…”

Bioavailability and Bioequivalence Study in Correlation of Biopharmaceutics Classification System (Bcs) and Possible Modification

“…A physical form having an improved dissolution rate and solubility is useful for improving the bioavailability of a drug 48,49 . The crystal habit is an important variable in pharmaceutical manufacturing, where some factors, such as the polarity of crystallization solvent and the presence of impurities in the solvent, affect crystallization [50][51][52] . Among them, solvent strongly affects the habit of crystalline materials; however, the roleplayed by solvent interactions in enhancing or inhibiting crystal growth is still not completely understood 53 .…”