Modification of acute myocardial infarction size with lidocaine in dogs

Plasma Concentrations and Cardiovascular Influence of Lidocaine Infusions During Isoflurane Anesthesia in Healthy Dogs and Dogs With Subaortic Stenosis

“…Another study in dogs with experimentally produced acute myocardial infarction showed that administration of lidocaine produced a negative inotropic effect manifested by a significant decrease in left ventricular change in pressurekhange in time. 32 We were unable to measure this parameter, although none of the other measurements revealed any evidence of inotropic depression. Our results are very similar to those found in humans with cardiac disease.…”