Modification of Apneusis by Afferent Vagal Stimulation

Kerr, Donald; Dunlop, Craig; Best, Effie D.; Mullner, Judith A.

doi:10.1152/ajplegacy.1954.176.3.508

Cited by 10 publications

(1 citation statement)

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“…The facilitation of expiration by lung inflation, observed in subject 1, is the Hering-Breuer reflex, which is facilitated by vagal inputs from lung stretch receptors to parabrachial nuclei (Kerr et al 1954, Feldman et al 1976, Parent 1996, Blessing 1997a. The temporary disappearance of apneusis during tube feeding in subject 1 can also be explained by vagal inputs from the alimentary tract, and the resulting rate of rapid shallow respiration was more rapid than the heart beat.…”

Section: Discussionmentioning

confidence: 96%

Apneustic breathing in children with brainstem damage due to hypoxic–ischemic encephalopathy

Saito¹,

Hashimoto²,

Iwata³

et al. 1999

Develop Med Child Neuro

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To confirm the presence of apneusis in patients with hypoxic–ischemic encephalopathy and to clarify which factors influence their respiratory patterns, polygraphic studies were performed on two patients. Apneusis was clinically suspected in both patients who had severe brainstem damage. In one subject, inputs of vagal afferents from the gastrointestinal tract and the urinary bladder often resulted in extreme tachypnea instead of apneusis. Lung inflation facilitated expiration during inspiratory arrest. Expiration preceded a periodic inhibition of rigospastic discharge in the right biceps muscle. In the other subject, prolonged inspiratory pauses with cyanosis occurred with or without preceding epileptic seizure. Both phenytoin dose reduction and treatment with tandospirone, a serotonin‐1A agonist, were effective in improving the respiratory distress in this subject.

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Section: Discussionmentioning

confidence: 96%