Modification of arabinogalactan and its oxidized forms with p-aminosalicylic acid

Polysaccharides from Larch Biomass

“…Such complexes of AG with 5-aminosalicylic acid show high antiulcer activity, while complexes incorporating 4-aminosalicylic or isonicotinic acid hydrazide demonstrate an antituberculosis effect. It has been established that conjugates of AG and products of its modification increase the physiological effect of MS and decrease their toxicity [28,[46][47][48]; for instance, a conjugate of AG (9kDa) 9--Darabinofuranosyladenine-5'-monophosphate was 25-fold more active than the parent compound 9--D-arabinofuranosyladenine (araA) in decreasing the amount of hepatitis B virus, and the toxicity of the complex preparation is much lower than araA [28]. To increase reactivity of AG with MS, the synthesis of conjugates proceeds by bromination, phosphorylation, amination, formation of hydrazides or reaction with NaBH4 [27,33,34].…”

“…It has been revealed that oligomeric products show anti-inflammatory and antiulcer activities. Reactions of AG and oxidized AG with some known MS give intermolecular complexes [46][47][48]. Such complexes of AG with 5-aminosalicylic acid show high antiulcer activity, while complexes incorporating 4-aminosalicylic or isonicotinic acid hydrazide demonstrate an antituberculosis effect.…”