Modification of ATP-sensitive K+ channels by proteolysis in smooth muscle cells from pig urethra

Teramoto, Noriyoshi; Tomoda, Toshihisa; Yunoki, Takakazu; Brading, Alison F.; Ito, Yushi

doi:10.1016/s0024-3205(02)02284-1

Cited by 3 publications

(1 citation statement)

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“…DNase I, one of the actin microfilament disrupters, has been shown to stimulate the activity of K ATP channels in cardiomyocytes (Terzic & Kurachi, 1996). Similarly, cytochalasin B enhanced the activity of K ATP channels in native K ATP channels of smooth muscle (Teramoto et al 2002). The actin filament network and its related proteins might be involved in signal transaction between the inhibitory regulatory proteins and K ATP channels.…”

Section: Interaction Between Cytoskeletal Network and The Regulatingmentioning

confidence: 99%

Physiological roles of ATP‐sensitive K⁺ channels in smooth muscle

Teramoto

2006

The Journal of Physiology

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109

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Potassium channels that are inhibited by intracellular ATP (ATP i ) were first identified in ventricular myocytes, and are referred to as ATP-sensitive K + channels (i.e. K ATP channels). Subsequently, K + channels with similar characteristics have been demonstrated in many other tissues (pancreatic β-cells, skeletal muscle, central neurones, smooth muscle). Approximately one decade ago, K ATP channels were cloned and were found to be composed of at least two subunits: an inwardly rectifying K + channel six family (Kir6.x) that forms the ion conducting pore and a modulatory sulphonylurea receptor (SUR) that accounts for several pharmacological properties. Various types of native K ATP channels have been identified in a number of visceral and vascular smooth muscles in single-channel recordings. However, little attention has been paid to the molecular properties of the subunits in K ATP channels and it is important to determine the relative expression of K ATP channel components which give rise to native K ATP channels in smooth muscle. The aim of this review is to briefly discuss the current knowledge available for K ATP channels with the main interest in the molecular basis of native K ATP channels, and to discuss their possible linkage with physiological functions in smooth muscle.

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Section: Interaction Between Cytoskeletal Network and The Regulatingmentioning

confidence: 99%