Modification of biologically active amides and amines with the fluorine-containing heterocycles 9. γ-Carbolines modified by the 2-trifluoromethylimidazo-[1,2-a]pyridin-6-yl fragment

Cycloalkaneindoles with 2-trifluoromethylimidazo[1,2-a]pyridin-6-yl fragment

“…Besides the gamma carboline derivatives [1][2][3][4][5][6], their tetrahydrocarbazole analogs containing the 2,3,4,5-tetrahydro-1Н-pyrido- [4,3-b]indole scaffold as well have been suggested as neuroprotective drugs; such compounds may act as antagonists of the 5-НТ 6 subtype of serotonin receptors [7] or inhibitors of peroxide oxidation of lipids [8], they exhibit the enhanced affinity towards NMDA receptors [9]. We have earlier demonstrated that introduction of the 2-trifluoromethylimidazo[1,2-а]pyridin-3-yl fragment into the gamma carbolines structure significantly improves their biological activity as compared to that of the parent compounds [5].…”