Modification of cellulose non-woven substrates for preparation of modern wound dressings

Abstract

Different ways are presented of modifying cellulosic non-woven substrates, which can serve as potential wound dressings with satisfactory antimicrobial and hydrophilic properties. For safe attachment of silver particles without a measurable release from the used materials, a sol–gel derived process was used. Alkaline and oxygen plasma treatments were used to improve the hydrophilicity of the materials. Their efficiency was determined by measuring contact angles and water retention values. Scanning electron microscopy (SEM) was used for determination of sample morphology prior to and after treatment. The efficiency of silver attachment and activity was evaluated by in vitro release studies and antimicrobial tests. Atomic force microscopy (AFM) and SEM, combined with dynamic light scattering, were used for determination of silver particle size. Additionally, we evaluated the influence of treatment on technological parameters, important for application performance, i.e. mechanical properties and air permeability.

Nonwoven Cellulose Substrates for Modern Wound Dressings

“…16.1) [32]. Evidently, the surface of the sample does not reveal that any site-specific changes can be observed on any sample surface.…”

“…The extent of change, resulting from different fiber treatment, varies from no morphological changes at all to highly altered surface features. The samples P, SP, and ASP, appear to exhibit most significant changes, where plasma treatment was the final procedure [32]. [32] This is due to the fact that plasma treatment not only leads to surface functionalization, but also affects the surface due to etching, that follows procedure of the plasma treatment.…”

“…The samples P, SP, and ASP, appear to exhibit most significant changes, where plasma treatment was the final procedure [32]. [32] This is due to the fact that plasma treatment not only leads to surface functionalization, but also affects the surface due to etching, that follows procedure of the plasma treatment. Of all the samples, sample P shows holes on the surface having a diameter of some hundred nm.…”

“…It has been shown that if less than 2 mg/L of silver is released within 24 h, no significant cytotoxic effect can be observed [10]. This value was taken into account during preparation of silvercoated fibrous substrates in such a way that its release would not exceed the limit value, and thereby a safe antimicrobial effect is achieved [32]. The solgel process has been used to bind silver nanoparticles safely on cellulose fibrous material.…”

Sol-gel/Ag coating and oxygen plasma treatment effect on synthetic wound fluid sorption by non-woven cellulose material

“…Plasma treatment is one of the most versatile techniques in polymer surface modifi cations [6] used for increasing wettability [7] and adhesion [8], while the best results are observed when using oxygen gas [9]. In our previous studies [10], we combined safe silver binding on cellulose substrate and oxygen plasma modifi cation aiming at achieving simultaneously antimicrobial properties along with improved hydrophilicity. Th e silver-containing samples showed minimal silver release while providing safe antimicrobial activity towards four most common present bacteria in wounds.…”