Modification of dental caries and calculus in rats by fluoride and bicarbonate-phosphate-fluoride additions to dietary sugar

Luoma, H; Meurman, Jukka H.; Helminen, Sari; Koskinen, Kaarina; Ranta, Helena

doi:10.1016/0003-9969(72)90025-8

Cited by 15 publications

(4 citation statements)

References 18 publications

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“…Several reports have advocated sugar as a vehicle for fluorides (Luoma et al, 1972;Manson-Hing et al, 1973;0strom et al, 1975;Turtola, 1977), and more recently animal studies with fluoridated sucrose (Mundorff et al, 1988) have shown a reduction in dental caries in rats. The theory of providing therapeutic levels of fluoride at the exact time that enamel is undergoing acid attack is attractive.…”

Section: Fluoride Supplementationmentioning

confidence: 96%

Water Fluoridation and Fluoride Supplementation: Considerations for the Future

1990

J Dent Res

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The extensive literature on water fluoridation and fluoride supplementation is discussed, looking critically at the benefits of systemic fluoride availability in the prevention of dental caries and at the adverse factors of enamel fluorosis which can occur from the ingestion of too much fluoride during the period of tooth development. Recommendations are made for the future use of fluorides, emphasizing that water fluoridation is a safe and proven health measure which should be continued. Caution in the use of other fluoride supplementation methods is raised, especially when related to compliance and the use of fluoride supplements which are under the control of the individual. Targeting of children who would benefit from fluorides and additional preventive dental health measures is recommended.

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Section: Fluoride Supplementationmentioning

confidence: 96%

Water Fluoridation and Fluoride Supplementation: Considerations for the Future

1990

J Dent Res

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“…caries-conducive potential, a standard supple-In a preceding experiment on rats,, a fluoride ment/sucrose ratio in all products would seem supplement of 15 mg F/kg of dietar)'sucrose (10 appropriate. Then the intake of fluoride and parts/lO^Finthe whole diet) was strongly cariesother supplements would be easy to calculate inhibitory, especially when supported by a buffer according to the known intake of sucrose in the combination (17). An addition of 10-20 supplemented products themselves.…”

mentioning

confidence: 99%

Caries reduction in rats through F + Mg supplementation of dietary sucrose with observations on bone mineral density and soft and hard tissue minerals

Luoma

Koskinen

Olkkonen

et al. 1982

European J Oral Sciences

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Caries reduction in rats through F + Mg supplementation of dietary sucrose with observations on bone mineral density and soft and hard tissue minerals. Scand. J. Dent. Res. 1982: 90: 345^353.Abstract -Two control diets with different sucrose contents (44% and 22%) were given to weanling rats for 55 d. The test diets were .sopplemenited with an F + Mg combination, 75 parts/10^ F as NaF+ 50 parts/10'' Mg as MgO and 38 parts/JO^ F + 25 parts/10*^ Mg, respectively, i.e. using the same suppSement/sucrose ratio in each test diet. The sopplementation in each test diet caused the same percentage fissure caries reduction, but the absolute mean caries scores were higher in the high-sucrose groups than in the respective low-sucrose groups,. Enamel solubility was reduced by the supplemenladon. Despite the high iliuoride supplementation, no untoward effects were recorded in growth and in aortiC;k eart, and renal calcium contents. Bone mineral density was reduced in the low-sucrose controls and slightly reduced in the high-sucrose F+Mg supplemented rats, as compared with the high-sucrose controls.

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“…This limit, in turn, may be lower if the general nutrition of the animal is imbalanced (11). The concentration of fluoride in the present diet was much higher than the concentration we used earlier (8,20). Since, however, higher fluoride additive, i.e.…”

Section: Discussionmentioning

confidence: 55%

Arrestment of caries in rats by adding fluoride and magnesium to the diet

Luoma

Koskinen

Luoma

1983

European J Oral Sciences

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– 90 weanling Osborne‐Mendel rats were divided into six groups of 15 animals each. Half of them received a modified MIT 200 control diet in which one third of the sucrose of the original formula was replaced by high‐extraction wheat flour, magnesium content reduced to 360 parts/106 and phosphorus content increased with NaH2PO4 2H2O to 0.49%. For the experimental diet, an additive containing 75 parts/106 fluoride (as NaF) and 50 parts/106 magnesium (as MgO) was mixed into the above composition. Each diet was given to three experimental or three control groups for 25, 40, or 55d. Caries involving dentin‐enamel junction was significantly reduced through the F + Mg addition by 37%, 51%, and 61% on the 25th, 40th, and 55th day, respectively. Caries involving dentin was significantly reduced by 58%, 68%, and 70%, respectively. Caries arrestment was observable in both the control rats and rats fed the F + Mg additive but in the latter animals the reduction meant an arrestment at a lower level than in controls. This arrestment resembles an early caries arrestment obtained recently in a clinical trial by fluoridation of dietary sugar products. The growth of the animals was only temporarily retarded by the additives.

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Modification of dental caries and calculus in rats by fluoride and bicarbonate-phosphate-fluoride additions to dietary sugar

Cited by 15 publications

References 18 publications

Water Fluoridation and Fluoride Supplementation: Considerations for the Future

Water Fluoridation and Fluoride Supplementation: Considerations for the Future

Caries reduction in rats through F + Mg supplementation of dietary sucrose with observations on bone mineral density and soft and hard tissue minerals

Arrestment of caries in rats by adding fluoride and magnesium to the diet

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