Modification of electrospun PI membranes with active chlorine for antimicrobial skin patches applications

Sroczyk, Ewa A.; Bryant, Jack A.; Cogan, Felicity de; Knapczyk‐Korczak, Joanna; Marzec, Mateusz; Szewczyk, Piotr K.; Banzhaf, Manuel; Stachewicz, Urszula

doi:10.1016/j.apsusc.2022.153302

Cited by 15 publications

(3 citation statements)

References 48 publications

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“…All the samples exhibited an average thickness ranging from approximately 0.70 to 0.85 mm, as depicted in Figure S3. We believe this thickness is suitable for their potential application as antimicrobial patches (e.g., for topical application in skin). − Furthermore, there is a noticeable change in color and intensity as the concentration of TPPF 20 -Zn increases: EC mats are entirely white, and the addition of TPPF 20 -Zn into the polymeric solution transforms the color to pink, corroborating the inclusion of the porphyrin. Additionally, the intensity is higher in the case of EC/TPPF 20 -Zn-2 compared to EC/TPPF 20 -Zn-1.…”

Section: Resultsmentioning

confidence: 75%

Light-Activated Antibacterial Ethylcellulose Electrospun Nanofibrous Mats Containing Fluorinated Zn(II) Porphyrin

González López,

Palacios,

Martinez

et al. 2024

ACS Appl. Polym. Mater.

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A system composed of ethylcellulose (EC) nanofibers loading with [5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato]zinc(II) (TPPF 20 -Zn) was developed as electrospun mats to contribute to the inactivation of resistant bacteria strains. This tetrapyrrolic macrocycle was chosen for its excellent photostability and straightforward large-scale preparation, which are crucial attributes for practical applications. The synthesis and subsequent characterization of TPPF 20 -Zn demonstrated scalability and its ability to generate reactive oxygen species (ROS). Subsequently, nanofibrous mats based on EC loaded with different amounts of the porphyrin were obtained using the single-nozzle electrospinning technique after dissolution in a binary solvent mix of N,Ndimethylacetamide/ethanol. The fibers exhibited an adequate morphology at the nanoscale, a narrow diameter distribution, and an absence of beads. Additionally, the thermal and surface properties of the systems were analyzed, revealing no significant changes upon porphyrin incorporation. The developed electrospun composite nanofibrous mats demonstrated the capability to photokill Escherichia coli, as confirmed in planktonic suspension and using advanced fluorescence microscopy. Considering all the studies reported herein, we believe that the EC/TPPF 20 -Zn mats show promise for practical application in the field of antimicrobial patches or self-sterilizing surfaces.

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Section: Resultsmentioning

confidence: 75%

Light-Activated Antibacterial Ethylcellulose Electrospun Nanofibrous Mats Containing Fluorinated Zn(II) Porphyrin

González López,

Palacios,

Martinez

et al. 2024

ACS Appl. Polym. Mater.

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“…The bands at 1362 cm −1 show the C-N stretch, and at 1721 cm −1 are related to the C=O stretch. [24][25][26] Moreover, the broad peak at 844 cm −1 demonstrates the Si-N stretch band in the spectrum of SiN nanoparticles. [27] It can be seen in Figure 2b that an increase in the SiN concentration resulted in peaks with higher intensity in the region 780 cm −1 -1100 cm −1 , proving the presence of nanoparticles in the electrospun nanofibers.…”

Section: Chemical Analysis and Mechanical Propertiesmentioning

confidence: 99%

Bridging a Gap in Thermal Conductivity and Heat Transfer in Hybrid Fibers and Yarns via Polyimide and Silicon Nitride Composites

Moradi

Szewczyk

Stachewicz

2023

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The pressing issues of the energy crisis and rapid electronics development have sparked a growing interest in the production of highly thermally conductive polymer composites. Due to the challenges related to the poor processability of hybrid materials and filler distribution to achieve high thermal conductivity, electrospinning is employed to create composite nanofibers and yarns using polyimide (PI) and thermally conductive silicon nitride (SiN) nanoparticles. The thermal performance of the individual nanofibers is evaluated using scanning thermal microscopy (SThM), providing significant insights into their heat transfer performance. Next, the nanofibers are applied as coatings on resistance wires to assess the thermal conductivity and insulation properties. Notably, the samples containing 35 wt.% of SiN exhibit a 25% increase in surface temperature. These innovative materials hold great promise as exceptional candidates for smart textiles and thermal management applications, addressing the growing demand for effective heat dissipation and regulation.

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“…The current methods for atopic skin treatment include avoiding irritating factors and two additional approaches: antimicrobial and ameliorating. Antimicrobial activity is realized by topical application of corticosteroids 17 and antimicrobial agents in the form of skin patches 18 or solutions to take a bath in. 19 Complementary atopic dermatitis therapy requires maintaining skin moisturized and is realized by the application of hydrating formulas such as creams, 20 emollients, 20 and natural oils.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol Nanofiber Patches with Sustainable Oil Delivery Eliminate Inflammation in Atopic Skin

Sroczyk,

Tarasiuk,

Talar

et al. 2024

ACS Appl. Mater. Interfaces

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Atopic skin is dry and itchy and lacks integrity. Impaired skin barrier results from altered lipid composition of the skin. A crucial skin lipid, cholesterol, provides flexibility and homeostasis of the cell membranes' lipid bilayer. Cholesterol-based creams and natural oils, especially blackcurrant seed oil, are beneficial for skin care as they hydrate the skin and improve its integrity. The major atopic symptom, skin dryness, can be overcome by the application of porous patches enhanced with cholesterol and natural oil. The base of the patches is constructed of polyimide (PI) nanofibers with cholesterol coatings and externally added blackcurrant seed oil. The presence of cholesterol in PI mats hinders the passage of oil through the patches to the skin, resulting in sustained and prolonged skin hydration. The theoretical and numerical investigations of oil dynamics in porous mats confirmed the experimental results, showing a prolonged skin hydration effect up to 6 h. Additionally, as demonstrated by in vivo tests on atopic mice, cholesterol patches lower serum immunoglobulin E levels and expression of proinflammatory cytokines in the skin, thereby accelerating skin healing. Our results hold great promise for the longterm application of the patches in atopic dermatitis treatment.

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Modification of electrospun PI membranes with active chlorine for antimicrobial skin patches applications

Cited by 15 publications

References 48 publications

Light-Activated Antibacterial Ethylcellulose Electrospun Nanofibrous Mats Containing Fluorinated Zn(II) Porphyrin

Light-Activated Antibacterial Ethylcellulose Electrospun Nanofibrous Mats Containing Fluorinated Zn(II) Porphyrin

Bridging a Gap in Thermal Conductivity and Heat Transfer in Hybrid Fibers and Yarns via Polyimide and Silicon Nitride Composites

Cholesterol Nanofiber Patches with Sustainable Oil Delivery Eliminate Inflammation in Atopic Skin

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