Modification of electrospun PVA/PAA scaffolds by cold atmospheric plasma: alignment, antibacterial activity, and biocompatibility

Arik, Nehir; Inan, Alper; Ibis, Fatma; Demirci, Emine Afra; Karaman, Ozan; Ercan, Utku Kürşat; Horzum, Nesrin

doi:10.1007/s00289-018-2409-8

Cited by 20 publications

(12 citation statements)

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“…In another study, Murrell et al reported that ROS significantly promotes the migration and proliferation of human fibroblasts [ 56 ]. In addition, we previously demonstrated that the NTAP-treated electrospun polyvinyl alcohol (PVA)/polyacrylic acid (PAA) nanofibers significantly increased the wound closure when extracted media was applied on the scratch assay developed by L929 mouse fibroblasts [ 57 ]. Therefore, we strongly speculated that extract media acts as an ROS transfer media to the scratch site and fastens wound closure by enhancing the fibroblast migration and proliferation.…”

Section: Discussionmentioning

confidence: 99%

Prevention of bacterial colonization on non-thermal atmospheric plasma treated surgical sutures for control and prevention of surgical site infections

et al. 2018

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Surgical site infections have a remarkable impact on morbidity, extended hospitalization and mortality. Sutures strongly contribute to development of surgical site infections as they are considered foreign material in the human body. Sutures serve as excellent surfaces for microbial adherence and subsequent colonization, biofilm formation and infection on the site of a surgery. Various antimicrobial sutures have been developed to prevent suture-mediated surgical site infection. However, depending on the site of surgery, antimicrobial sutures may remain ineffective, and antimicrobial agents on them might have drawbacks. Plasma, defined as the fourth state of matter, composed of ionized gas, reactive oxygen and nitrogen species, free radical and neutrals, draws attention for the control and prevention of hospital-acquired infections due to its excellent antimicrobial activities. In the present study, the efficacy of non-thermal atmospheric plasma treatment for prevention of surgical site infections was investigated. First, contaminated poly (glycolic-co-lactic acid), polyglycolic acid, polydioxanone and poly (glycolic acid-co-caprolactone) sutures were treated with non-thermal atmospheric plasma to eradicate contaminating bacteria like Staphylococcus aureus and Escherichia coli. Moreover, sutures were pre-treated with non-thermal atmospheric plasma and then exposed to S. aureus and E. coli. Our results revealed that non-thermal atmospheric plasma treatment effectively eradicates contaminating bacteria on sutures, and non-thermal atmospheric plasma pre-treatment effectively prevents bacterial colonization on sutures without altering their mechanical properties. Chemical characterization of sutures was performed with FT-IR and XPS and results showed that non-thermal atmospheric plasma treatment substantially increased the hydrophilicity of sutures which might be the primary mechanism for the prevention of bacterial colonization. In conclusion, plasma-treated sutures could be considered as novel alternative materials for the control and prevention of surgical site infections.

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Section: Discussionmentioning

confidence: 99%

Prevention of bacterial colonization on non-thermal atmospheric plasma treated surgical sutures for control and prevention of surgical site infections

et al. 2018

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“…It is a non-toxic polymer, soluble in water; it makes the blends, owing to the presence of -OH groups that are accountable for Hydrogen bond formation. PVA is competent in replicating the natural tissues, contact lenses, a lining of artificial organs, drug delivery system [9].…”

Section: Introductionmentioning

confidence: 99%

Blends of synthetic plastic-derived polypeptide with Hydroxypropylmethylcellulose and polyvinyl alcohol: unraveling the specific interaction parameters, morphology and thermal stability of the polymers couple

et al. 2020

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The medleys of the plastic-derived polypeptide with commercially available polymers believably the suitable candidate for pharmaceutical and biomedical importance. The current research is focussed on the synthesis of a novel plastic-mimetic polypeptide (PLP), poly(IPAVG) by the solution phase method (where I, P, A, V, and G represent Isoleucine, Proline, Alanine, Valine, and Glycine, respectively). The miscibility attributes of PLP/polyvinyl alcohol (PVA) and PLP/ hydroxypropylmethylcellulose (HPMC) blends were examined by viscometry and by other advanced analytical tools for different weight proportions. It is shown by the viscometry that the PLP/HPMC and PLP/PVA form an immiscible blend system at 10 ο C and further, the FTIR spectra of poly (IPAVG) /HPMC and poly (IPAVG) /PVA blend membranes manifest the lack of intermolecular interactions. DSC results proved the dual Tg for one blend proportion and lower Tg values for all other blend systems. The thermal property of the blends with different compositions was evaluated by thermogravimetric analysis (TGA). The TGA results showed that the blends possess inferior thermal stability to the native ones. The surface morphology was analyzed by SEM indicated the heterogeneity and X-ray diffraction (XRD) revealed the absence of any change in crystallinity advocated the immiscibility of the blends. Further, we ventured to prepare the non-woven fabrics from the solutions of 1-10 wt% concentrations at the voltages within 20-30 kV by electrospinning. The droplet formed at the spinneret failed to reach the collector plate, and consequently, no films developed for the collector device.

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“…Electrospinning is used to produce random and aligned PAA/PVA nanofiber scaffolds treated with cold atmospheric plasma. It has shown reasonably good antibacterial activity against E. coli [ 256 ]. Dil et al reported the development of a nanocomposite hydrogel based on PAA, gelatin, and nanosilver, which demonstrated great antibacterial activity against harmful bacteria such as S. aureus and E. coli [ 257 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA. For example, nano-particles produced from PAA derivatives can be used to deliver drugs due to their stability and biocompatibility. PAA and its nanoconjugates could also be regarded as stimuli-responsive platforms that make them ideal for drug delivery and antimicrobial applications. These properties make PAA a good candidate for conventional and novel drug carrier systems. Here, we started with synthesis approaches, structure characteristics, and other architectures of PAA nanoplatforms. Then, different conjugations of PAA/nanostructures and their potential in various fields of nanomedicine such as antimicrobial, anticancer, imaging, biosensor, and tissue engineering were discussed. Finally, biocompatibility and challenges of PAA nanoplatforms were highlighted. This review will provide fundamental knowledge and current information connected to the PAA nanoplatforms and their applications in biological fields for a broad audience of researchers, engineers, and newcomers. In this light, PAA nanoplatforms could have great potential for the research and development of new nano vaccines and nano drugs in the future.

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Modification of electrospun PVA/PAA scaffolds by cold atmospheric plasma: alignment, antibacterial activity, and biocompatibility

Cited by 20 publications

References 50 publications

Prevention of bacterial colonization on non-thermal atmospheric plasma treated surgical sutures for control and prevention of surgical site infections

Prevention of bacterial colonization on non-thermal atmospheric plasma treated surgical sutures for control and prevention of surgical site infections

Blends of synthetic plastic-derived polypeptide with Hydroxypropylmethylcellulose and polyvinyl alcohol: unraveling the specific interaction parameters, morphology and thermal stability of the polymers couple

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

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