Modification of Human Pericardium by Chemical Crosslinking

Filová, Elena; Staňková, Lubica; Eckhardt, Adam; Svobodová, Jana; Musı́lková, Jana; Pala, Jan; Hadraba, Daniel; Brynda, Eduard; Koňařík, Miroslav; Jan, Pirk; Bačáková, Lucie

doi:10.33549/physiolres.934335

Cited by 13 publications

(13 citation statements)

References 26 publications

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“…The heterogeneous pericardial tissue is rich in amino, hydroxyl, carboxyl and other active functional groups, providing a variety of chemical cross-linking possibilities. Therefore, recent studies have used non-GA fixation strategies for acellular matrix such as genipin, [15,93] carbodiimide [94][95][96] and other crosslinkers [12,[97][98][99] to reduce the calcification of biological valves and improve blood compatibility. Yang et al prepared a zwitterionic-polymer porcine pericardium by in-situ copolymerization.…”

Section: New Cross-linking Methodsmentioning

confidence: 99%

Prosthetic heart valves for transcatheter aortic valve replacement

Peng

et al. 2023

BMEMat

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Transcatheter aortic valve replacement (TAVR) has the advantages of less trauma and faster postoperative recovery, which has brought the possibility to the elderly patient with valvular heart disease and is gradually replacing surgical aortic valve replacement (SAVR). The interventional valve used in TAVR needs to be compressed and transported through the catheter to the lesion site, and can still recover its original shape, structure and performance. This process requires that the material should be flexible, and the rigid mechanical valves in SAVR are not suitable. Recently, decellularized biological valves have been widely used in clinical practice, but their poor durability causes a limitation for long-term implantation. Therefore, the anti-calcification modification of biological valves and the design of new polymeric valves with good biostability have gained considerable attention. This review summarizes the calcification mechanism of biological valves and the research progress in anti-calcification modification strategies. Besides, the development of new polymeric valves is included, withThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: New Cross-linking Methodsmentioning

confidence: 99%

Prosthetic heart valves for transcatheter aortic valve replacement

Peng

et al. 2023

BMEMat

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“…With the developments in technology, the number and variety of bio-prosthesis materials used in cardiovascular surgery are increasing. Compared to synthetic materials, pericardial patches are an inexpensive, readily available, infection-resistant, and biocompatible material (12). Autologous pericardium can be used fresh or treated with glutaraldehyde.…”

Section: Discussionmentioning

confidence: 99%

Eş zamanlı karotis endarterektomi ve koroner arter baypas greftleme operasyonu yapılan hastalarda otolog perikard alternatif bir karotis yama materyali olabilir.

et al. 2022

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Backround: Dacron, polytetrafluoroethylene, great saphenous vein, and bovine pericardium are the commonly used as patch materials. However, there is no study about autologous pericardial as a patch material in carotid endarterectomy surgery. We aimed to assess the results of the use of autologous pericardial patch in patients undergoing concomitant carotid endarterectomy and coronary artery by-pass graft surgery. Materials and Methods:: The study involved 30 patients who underwent concomitant carotid endarterectomy with patch angioplasty and coronary artery bypass grafting surgery from January 2016 to February 2020. Patchplasty is performed with autologous pericardium for 13 patients and dacron patch for 17 patients during carotid endarterectomy. Results: No statistical difference was found between the groups in terms of reoperation, arterial occlusion, restenosis, operation time, and neurological events. In the postoperative follow-up, it was determined that the amount of drainage from the area on which the carotid surgery was applied was less in the those in whom autologous pericardium was used compared to those in whom Dacron patch was used. (p=0.001) Conclusion: We concluded that the use of autologous pericardium as a carotid artery patch is a safe, feasible, and effective method in patients undergoing combined carotid artery and coronary bypass surgery.

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“…14 Crosslinking pericardium grafts with genipin therefore seems to be a promising alternative procedure to the crosslinking with GA, because it provides similarly high protection against degradation with collagenase, without cytotoxic effects. 13 GA-treated pericardium has been occasionally used in the field of cardiovascular surgery as a material for atrial septal defect closure and aortic valvuloplasty. [4][5][6] Xenopericardium, fresh pericardium, and GA-treated pericardium have been widely used in mitral valve repair.…”

Section: Discussionmentioning

confidence: 99%

Partial Tracheal Defects Closure using Glutaraldehyde-Treated Autologous Pericardium

Yoshida

Matsumoto

Saito

et al. 2022

Thorac Cardiovasc Surg

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Background The usefulness of autologous pericardium treated with glutaraldehyde (GA) for tracheal defect closure is unknown. This study preliminarily evaluated whether a GA-treated autologous pericardial graft can effectively close tracheal defects in a beagle model. Methods Defects of 10 mm × 10 mm were created on the trachea of 10 beagles and divided into a GA-treated group (n = 5), with tracheal reconstruction using GA-treated pericardium, and control group (n = 5), using fresh pericardium. Repair sites were evaluated through bronchoscopy and histology. Blood flows on graft were measured using laser Doppler technique on postoperative days (PODs) 0, 4, 7, 14, 28, and 56. Repair sites were histologically evaluated on POD 56. In addition, GA-treated pericardia of three other beagles were histologically evaluated 12 months postoperatively, for long-term follow-up. Results All animals survived; none developed anastomotic insufficiency. The mean suturing time and frequency of additional suture were significantly shorter and lower in the GA-treated group than in the control group (p = 0.002, 0.004). All animals in the control group exhibited graft contraction, whereas the GA-treated group healed with most graft residual and reepithelialization in the bronchoscopic and histological findings (p = 0.01, 0.004). Further, all long-term GA-treated pericardia of three beagles were confirmed as residual grafts with reepithelialization, without contraction, at 12 months postoperatively. Blood flows on graft using laser Doppler technique in the GA-treated group were detected at POD 14 or thereafter. Conclusion GA-treated pericardium was easier to handle and provided favorable scaffolding, without graft contraction, compared with the nontreated pericardium at short- and long-term follow-up.

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Modification of Human Pericardium by Chemical Crosslinking

Cited by 13 publications

References 26 publications

Prosthetic heart valves for transcatheter aortic valve replacement

Prosthetic heart valves for transcatheter aortic valve replacement

Eş zamanlı karotis endarterektomi ve koroner arter baypas greftleme operasyonu yapılan hastalarda otolog perikard alternatif bir karotis yama materyali olabilir.

Partial Tracheal Defects Closure using Glutaraldehyde-Treated Autologous Pericardium

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