Modification of membrane heterogeneity by antipsychotic drugs: An X-ray diffraction comparative study

Tessier, C.; Nuss, Philippe; Staneva, Galya; Wolf, Claude

doi:10.1016/j.jcis.2008.01.034

Cited by 32 publications

(34 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antipsychotic drugs could alter extracellular levels of neurotransmitters and thereby modify the development of the CNS [43]–[46]. These changes suggest that the neuroanatomy is severely affected by exposure to free Risp but to a lesser extent than by DG4.5-Risp.…”

Section: Resultsmentioning

confidence: 99%

Optimization and In Vivo Toxicity Evaluation of G4.5 Pamam Dendrimer-Risperidone Complexes

et al. 2014

View full text Add to dashboard Cite

Risperidone is an approved antipsychotic drug belonging to the chemical class of benzisoxazole. This drug has low solubility in aqueous medium and poor bioavailability due to extensive first-pass metabolism and high protein binding (>90%). Since new strategies to improve efficient treatments are needed, we studied the efficiency of anionic G4.5 PAMAM dendrimers as nanocarriers for this therapeutic drug. To this end, we explored dendrimer-risperidone complexation dependence on solvent concentration, pH and molar relationship. The best dendrimer-risperidone incorporation (46 risperidone molecules per dendrimer) was achieved with a mixture of chloroform:methanol 50∶50 v/v solution pH 3. In addition, to explore the possible effects of this complex, in vivo studies were carried out in the zebrafish model. Changes in the development of dopaminergic neurons and motoneurons were studied using tyrosine hydroxylase and calretinin, respectively. Physiological changes were studied through histological sections stained with hematoxylin-eosin to observe possible morphological brain changes. The most significant changes were observed when larvae were treated with free risperidone, and no changes were observed when larvae were treated with the complex.

show abstract

Section: Resultsmentioning

confidence: 99%

Optimization and In Vivo Toxicity Evaluation of G4.5 Pamam Dendrimer-Risperidone Complexes

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Other experiments showed that injections of chlorpromazine in dogs caused a significant increase in the AChE on the brains of experimental animals (Bareggi and Giacobini, 1978). The interference of antipsychotics with AChE is not absolutely surprising, since these drugs may interact with the lipid arrangement at the neuronal membrane, being likely to change membrane biological properties (Tessier et al, 2008). This can indeed cause changes in membrane bilayer environment, stimulating the inhibitory effect observed on acetylcholinesterase activity for in vitro experiments (Seibt et al, 2009).…”

Section: Chlorpromazinementioning

confidence: 98%

Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers

Oliveira

Antunes

Gonçalves

et al. 2015

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

“…Various studies have demonstrated that antipsychotic drugs have high affinity for biological membranes due to their amphipathic and amphiphilic properties, and this implies that antipsychotic drugs can interact with membrane lipid organization. It is known that antipsychotic intercalation in the membrane can alter the membrane lipid dynamics, possibly leading to modification of the receptor response (Tessier et al 2008). Accordingly, it is possible to hypothesize that changes in membrane structure induced by haloperidol might be responsible for the inhibitory effect observed on NTPDase and ADA activities in zebrafish brain membranes, which could not be induced by sulpiride and olanzapine.…”

Section: Discussionmentioning

confidence: 99%

Investigation into effects of antipsychotics on ectonucleotidase and adenosine deaminase in zebrafish brain

Seibt

Oliveira

Bogo

et al. 2015

Fish Physiol Biochem

View full text Add to dashboard Cite

Antipsychotic agents are used for the treatment of psychotic symptoms in patients with several brain disorders, such as schizophrenia. Atypical and typical antipsychotics differ regarding their clinical and side-effects profile. Haloperidol is a representative typical antipsychotic drug and has potent dopamine receptor antagonistic functions; however, atypical antipsychotics have been developed and characterized an important advance in the treatment of schizophrenia and other psychotic disorders. Purine nucleotides and nucleosides, such as ATP and adenosine, constitute a ubiquitous class of extracellular signaling molecules crucial for normal functioning of the nervous system. Indirect findings suggest that changes in the purinergic system, more specifically in adenosinergic activity, could be involved in the pathophysiology of schizophrenia. We investigated the effects of typical and atypical antipsychotics on ectonucleotidase and adenosine deaminase (ADA) activities, followed by an analysis of gene expression patterns in zebrafish brain. Haloperidol treatment (9 µM) was able to decrease ATP hydrolysis (35%), whereas there were no changes in hydrolysis of ADP and AMP in brain membranes after antipsychotic exposure. Adenosine deamination in membrane fractions was inhibited (38%) after haloperidol treatment when compared to the control; however, no changes were observed in ADA soluble fractions after haloperidol exposure. Sulpiride (250 µM) and olanzapine (100 µM) did not alter ectonucleotidase and ADA activities. Haloperidol also led to a decrease in entpd2_mq, entpd3 and adal mRNA transcripts. These findings demonstrate that haloperidol is an inhibitor of NTPDase and ADA activities in zebrafish brain, suggesting that purinergic signaling may also be a target of pharmacological effects promoted by this drug.

show abstract

Modification of membrane heterogeneity by antipsychotic drugs: An X-ray diffraction comparative study

Cited by 32 publications

References 25 publications

Optimization and In Vivo Toxicity Evaluation of G4.5 Pamam Dendrimer-Risperidone Complexes

Optimization and In Vivo Toxicity Evaluation of G4.5 Pamam Dendrimer-Risperidone Complexes

Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers

Investigation into effects of antipsychotics on ectonucleotidase and adenosine deaminase in zebrafish brain

Contact Info

Product

Resources

About