Modification of nanofibrous scaffolds to mimic extracellular matrix in physical and chemical structuring

Abstract

Regulating the surface chemistry and topography of the scaffolds is an effective way to improve the scaffolds' biocompatibility. A nanofibrous scaffold with topographical and chemical biomimicry to ECM was developed in this study. In which, PCL nanofibrous scaffold was employed as a substrate which was shish-kebab structured first to provide the topographical similarity with ECM and then coated with polydopamine and arginylglycylaspartic acid (RGD) to

Electrospun fibers modified with polydopamine for enhancing human mesenchymal stem cell culture

“…These results indicated that the PDA and PDA/RGD coatings can modify the hydrophobicity of pristine PCL fibers due to the presence of the carboxyl and amine groups provided by PDA and RGD. In a previous study, researchers demonstrated that grafting RGD onto PDA-coated PCL fibers resulted in better wettability than the PDAcoated fibers [32,34]. Similarly, our results suggest that the PDA/RGD copolymerization coating method is a simple procedure that increases wettability in only one step.…”

An integrative approach for the design of bioactive polycaprolactone‐based scaffold for bone tissue engineering

“…[10,11] Further, various fabrication techniques were employed, including 3D printing, the sol-gel process, lyophilization, electrospinning, porogen leaching, and gas foaming, among others. [6,[11][12][13] Nevertheless, existing scaffolds are still far from being adopted for successful clinical usage, as many requirements for bone regeneration contradict each other. [14] For example, high porosity is essential for nutrients and cell diffusivity; however, on the downside, it leads to poor mechanical properties.…”