Modification of quercetin by (dodecylsulfanyl)methyl group

Bagavieva, T. K.; Yagunov, S. E.; Kholshin, S. V.; Просенко, А. Е.

doi:10.1007/s11172-019-2438-y

Cited by 5 publications

(1 citation statement)

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“…One of the directions of this search is the modifi cation of natural biologically active substances. [1][2][3][4] From this viewpoint, 4H-chromen-4-one derivatives that are a subclass of fl avonoids, secondary metabolites of plants, are of great interest. The convenient precursors for the synthesis of heterocyclic analogs and homologs of isofl avones are 3-formylchromones (1) and, in particular compound 1a (R = H).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of heterocyclic analogs of isoflavone and homoisoflavone based on 3-formylchromone

et al. 2021

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The review is focused on recent developments of chemistry of synthetic analogs of natural compounds, isofl avone and homoisofl avone. The possible synthetic strategies to access heterocyclic analogs of these compounds starting from readily available 3-formylchromone and its derivatives (3-cyanochromone, 2-amino-3-formylchromone) and products of its condensation with simplest Cand N-nucleophiles are discussed. The structural features of the reaction products that depend on the nature of the reaction medium, structure of the starting compounds, and reagent ratio are considered. Particular attention is given to the application of the modern strategies of organic synthesis, namely green chemistry approaches, click reactions, domino reactions, etc. Examples of compounds of this group most promising for clinical application due to wide and pronounced pharmacological eff ects are given.

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Section: Introductionmentioning

confidence: 99%