Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

Schwarz, Katharina; Dobiasch, Sophie; Nguyen, Lily; Schilling, Daniela; Combs, Stephanie E.

doi:10.1038/s41598-020-60765-1

Cited by 38 publications

(28 citation statements)

References 57 publications

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“…In recent years, more and more researchers reported that active compounds from Chinese herbs such as curcumin, 69–71 resveratrol, 72–74 dihydroartemisinin 75–77 and paclitaxel, 78–80 could enhance tumor radiotherapy sensitivity ( Figure 2 ). Curcumin is a polyphenolic active compound extracted from turmeric.…”

Section: Small Moleculesmentioning

confidence: 99%

Application of Radiosensitizers in Cancer Radiotherapy

Gong¹,

Zhang²,

Liu³

et al. 2021

IJN

278

158

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Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. Although great success has been achieved on radiotherapy, there is still an intractable challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Radiosensitizers are chemicals or pharmaceutical agents that can enhance the killing effect on tumor cells by accelerating DNA damage and producing free radicals indirectly. In most cases, radiosensitizers have less effect on normal tissues. In recent years, several strategies have been exploited to develop radiosensitizers that are highly effective and have low toxicity. In this review, we first summarized the applications of radiosensitizers including small molecules, macromolecules, and nanomaterials, especially those that have been used in clinical trials. Second, the development states of radiosensitizers and the possible mechanisms to improve radiosensitizers sensibility are reviewed. Third, the challenges and prospects for clinical translation of radiosensitizers in oncotherapy are presented.

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Section: Small Moleculesmentioning

confidence: 99%

Application of Radiosensitizers in Cancer Radiotherapy

Gong¹,

Zhang²,

Liu³

et al. 2021

IJN

278

158

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“…PANC-1 cells were radiosensitized after 24 h of incubation with 10 (4 Gy: p = 0.0048, 6 Gy: p = 0.0096) or 12 µm of Curcumin (4 Gy: p = 0.0028, 6 Gy p = 0.0003, 8 Gy: p = 0.00070) whereas MiaPaCa-2 cells showed no significant radiosensitization. Furthermore, curcumin increased radiation induced apoptosis in both cells lines after 8 Gy exposure (PANC-1: p = 0.0174, MiaPaCa-2: p = 0.0043) [74]. This research also identified curcumin induced DNA damage via γ-H2AX evaluation and radiation induced G2/M arrest [74].…”

Section: Natural Radiosensistisersmentioning

confidence: 55%

“…Furthermore, curcumin increased radiation induced apoptosis in both cells lines after 8 Gy exposure (PANC-1: p = 0.0174, MiaPaCa-2: p = 0.0043) [74]. This research also identified curcumin induced DNA damage via γ-H2AX evaluation and radiation induced G2/M arrest [74].…”

Section: Natural Radiosensistisersmentioning

confidence: 55%

“…All three extracts conferred radiation inhibited cell survival, apoptosis and NF-κB expression [73]. More recently, Schwarz et al also investigated the radiosensitivity of pancreatic cancer cells lines to Curcumin longa root extract [74]. The pancreatic cancer cell lines PANC-1 and MiaPaCa-2 clonogenic survival fraction was reduced to 50% when treated with a 9.5 and 9 µm of Curcumin.…”

Section: Natural Radiosensistisersmentioning

confidence: 99%

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Novel Anticancer and Treatment Sensitizing Compounds against Pancreatic Cancer

Wishart

Gupta

Nisbet

et al. 2021

Cancers

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The isolation of chemical compounds from natural origins for medical application has played an important role in modern medicine with a range of novel treatments having emerged from various natural forms over the past decades. Natural compounds have been exploited for their antioxidant, antimicrobial and antitumor capabilities. Specifically, 60% of today’s anticancer drugs originate from natural sources. Moreover, the combination of synthetic and natural treatments has shown applications for (i) reduced side effects, (ii) treatment sensitization and (iii) reduction in treatment resistance. This review aims to collate novel and natural compounds that are being explored for their preclinical anticancer, chemosensitizing and radiosensitizing effects on Pancreatic Ductal Adenocarcinoma (PDAC), which is a lethal disease with current treatments being inefficient and causing serve side effects. Two key points are highlighted by this work: (i) the availability of a range of natural compounds for potentially new therapeutic approaches for PDAC, (ii) potential synergetic impact of natural compounds with advanced chemo- and radio-therapeutic modalities for PDAC.

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“…A limiting factor that could hinder the efficacy of this treatment modality in cancer patients is the low bioavailability and chemical instability of Curcumin (144). Indeed, obtaining a blood concentration of Curcumin comparable to the ones used in in vitro studies represents a great challenge that could be overcome improving the absorption through coating it in nanoparticles, liposomes or phospholipid complexes (145,146). For what concerns nanoparticles, a phase II clinical trial in which Nanocurcumin is coupled to Radiotherapy (RT) is ongoing in prostate cancer patients (ClinicalTrials.gov number, NCT02724618), and it will hopefully provide new insights on the potential advantages given by a different Curcumin delivery.…”

Section: Pathways Involved In Nf-kb-mediated Radioresistancementioning

confidence: 99%

Radiation Resistance: A Matter of Transcription Factors

2021

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Currently, radiation therapy is one of the standard therapies for cancer treatment. Since the first applications, the field of radiotherapy has constantly improved, both in imaging technologies and from a dose-painting point of view. Despite this, the mechanisms of resistance are still a great problem to overcome. Therefore, a more detailed understanding of these molecular mechanisms will allow researchers to develop new therapeutic strategies to eradicate cancer effectively. This review focuses on different transcription factors activated in response to radiotherapy and, unfortunately, involved in cancer cells’ survival. In particular, ionizing radiations trigger the activation of the immune modulators STAT3 and NF-κB, which contribute to the development of radiation resistance through the up-regulation of anti-apoptotic genes, the promotion of proliferation, the alteration of the cell cycle, and the induction of genes responsible for the Epithelial to Mesenchymal Transition (EMT). Moreover, the ROS-dependent damaging effects of radiation therapy are hampered by the induction of antioxidant enzymes by NF-κB, NRF2, and HIF-1. This protective process results in a reduced effectiveness of the treatment, whose mechanism of action relies mainly on the generation of free oxygen radicals. Furthermore, the previously mentioned transcription factors are also involved in the maintenance of stemness in Cancer Stem Cells (CSCs), a subset of tumor cells that are intrinsically resistant to anti-cancer therapies. Therefore, combining standard treatments with new therapeutic strategies targeted against these transcription factors may be a promising opportunity to avoid resistance and thus tumor relapse.

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Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

Cited by 38 publications

References 57 publications

Application of Radiosensitizers in Cancer Radiotherapy

Application of Radiosensitizers in Cancer Radiotherapy

Novel Anticancer and Treatment Sensitizing Compounds against Pancreatic Cancer

Radiation Resistance: A Matter of Transcription Factors

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