Modification of radiosensitivity of rat thymocytes by cholesterol-enriched autoliposomes

Effects of experimental hyperlipidemia on apoptosis and proliferation of thymocytes in response to mitogens were studied in CBA and C57Bl/6 mice. The concentrations of cholesterol in the serum and thymocyte membranes increased in both mouse strains. Spontaneous and dexamethasone-induced apoptosis in vitro and the proliferative response to phytohemagglutinin and concanavalin A were enhanced in thymocytes from C57Bl/6 mice and suppressed in cells from CBA mice. These data suggest opposite reactions of thymocyte to increased serum cholesterol concentration in these two strains, associated with stimulation and suppression of cell activity.

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Cholesterol induced variations of membrane dynamics related to the induction of apoptosis in mouse thymocytes

Härtel

Ojeda²,

Diehl³

1998

International Journal of Radiation Biology

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Cholesterol exerts specific rigidity effects on lipid membranes which have been shown to be involved in thymocyte apoptosis. The general effect of higher concentrations of cholesterol protecting against apoptosis hints towards a central protective mechanism. This study believes that either cholesterol paralyses great parts of the cell metabolism or that the apoptotic chain reaction is interrupted at a central point due to protection of membrane lipid regions from oxidative stress.

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Modification of radiosensitivity of rat thymocytes by cholesterol-enriched autoliposomes

Cited by 4 publications

References 6 publications

Effect of hyperlipidemia on thymocyte sensitivity to apoptosis in CBA and C57Bl/6 mice

Effect of hyperlipidemia on thymocyte sensitivity to apoptosis in CBA and C57Bl/6 mice

Effect of hyperlipidemia on thymocyte sensitivity to apoptosis in CBA and C57B1/6 mice

Cholesterol induced variations of membrane dynamics related to the induction of apoptosis in mouse thymocytes

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