Modification of release and penetration behavior of water-soluble active ingredient from ball-milled glutinous starch matrix via carboxymethylcellulose blending

Limpongsa, Ekapol; Soe, May Thu; Jaipakdee, Napaphak

doi:10.1016/j.ijbiomac.2021.11.059

Cited by 8 publications

(3 citation statements)

References 41 publications

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“…Weight uniformity of the films was assessed by taking five random samples ( n = 5) (1 × 1 cm 2 ), and the weight of each sample was calculated individually through an electronic weighing balance (OHAUS adventurer Analytical balance, USA) . The folding endurance of the hydrogel films was determined manually by folding the films at the same point for many times, and the number of times a film could be folded without any crack or breaking was noted as the value of folding strength of each film sample . The results of all parameters were reported as mean ± SD.…”

Section: Methodsmentioning

confidence: 99%

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Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

et al. 2023

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Curcumin (Cur) entrapped poly(vinyl alcohol) (PVA)/gelatin composite films were prepared by cross-linking with tannic acid (TA) as bioactive dressings for rapid wound closure. Films were evaluated for mechanical strength, swelling index, water vapor transmission rate (WVTR), film solubility, and in-vitro drug release studies. SEM revealed uniform and smooth surfaces of blank (PG9) and Cur-loaded composite films (PGC4). PGC4 exhibited excellent mechanical strength (tensile strength (TS) and Young’s modulus (YM) were 32.83 and 0.55 MPa, respectively), swelling ability (600–800% at pH 5.4, 7.4, and 9), WVTR (2003 ± 26), and film solubility (27.06 ± 2.0). Sustained release (81%) of the encapsulated payload was also observed for 72 h. The antioxidant activity determined by DPPH free radical scavenging showed that the PGC4 possessed strong % inhibition. The PGC4 formulation displayed higher antibacterial potential against S. aureus (14.55 mm zone of inhibition) and E. coli (13.00 mm zone of inhibition) compared to blank and positive control by the agar well diffusion method. An in-vivo wound healing study was carried out on rats using a full-thickness excisional wound model. Wounds treated with PGC4 showed very rapid healing about 93% in just 10 days post wounding as compared to 82.75% by Cur cream and 80.90% by PG9. Furthermore, histopathological studies showed ordered collagen deposition and angiogenesis along with fibroblast formation. PGC4 also exerted a strong anti-inflammatory effect by downregulating the expression of pro-inflammatory cytokines (TNF-α and IL-6 were lowered by 76% and 68% as compared to the untreated group, respectively). Therefore, Cur-loaded composite films can be an ideal delivery system for effective wound healing.

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Section: Methodsmentioning

confidence: 99%

“… 22 The folding endurance of the hydrogel films was determined manually by folding the films at the same point for many times, and the number of times a film could be folded without any crack or breaking was noted as the value of folding strength of each film sample. 23 The results of all parameters were reported as mean ± SD.…”

Section: Methodsmentioning

confidence: 99%

Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

et al. 2023

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“…K 0 , K H , and K KP are the zero-order, Higuchi, and Korsmeyer–Peppas rate constants, respectively. To interpret the release mechanism, the n, denoted as the release exponent, was determined from the slope of the plot between the log value of

, where the fractional DA released ≤60%, and log t , Equation (5) [ 37 , 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Formulation and In Vitro Evaluation of Mucoadhesive Sustained Release Gels of Phytoestrogen Diarylheptanoids from Curcuma comosa for Vaginal Delivery

et al. 2023

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Diarylheptanoids (DAs) characterized by a 1,7-diphenylheptane structural skeleton are considered a novel class of phytoestrogens. The DAs available in Curcuma comosa Roxb. (C. comosa) extract demonstrated significant estrogenic activities both in vitro and in vivo. This study aimed to develop and comprehensively evaluate a mucoadhesive vaginal gel for the sustained release of DAs. Different mucoadhesive polymers as gelling agents were investigated. C. comosa ethanolic crude extract was used as a source of DAs. All C. comosa gels were light brown homogeneous with pH within 4.4–4.6. Their flow behaviors were pseudoplastic with a flow behavior index of 0.18–0.38. The viscosity at a low shear rate varied from 6.2 to 335.4 Pa·s. Their mechanical and extrudability properties were associated well with rheological properties. Polycarbophil (PCP):hydroxypropyl methylcellulose (HPMC) blends had a higher mucoadhesiveness to porcine vaginal mucosa than those of PCP-based or HPMC-based gels. All C. comosa gels exhibited a sustained, zero-order DA release pattern over 72 h. Korsmeyer and Peppas equation fitting indicated a non-Fickian, case II transport release mechanism. C. comosa gels had good physical and chemical stability under low-temperature storage for up to 12 months. PCP:HPMC-based mucoadhesive gels could be a proper delivery system for vaginal administration of DAs.

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The pH role in casein-carboxymethylcellulose nano/microparticles formation

Souza,

Tartare,

Bega

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Modification of release and penetration behavior of water-soluble active ingredient from ball-milled glutinous starch matrix via carboxymethylcellulose blending

Cited by 8 publications

References 41 publications

Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

Formulation and In Vitro Evaluation of Mucoadhesive Sustained Release Gels of Phytoestrogen Diarylheptanoids from Curcuma comosa for Vaginal Delivery

The pH role in casein-carboxymethylcellulose nano/microparticles formation

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