Modification of Severe Coxsackievirus B ₃ Infection in Marasmic Mice by Transfer of Immune Lymphoid Cells

Abstract

Coxsackievirus causes severe disease in adult mice subjected to sustained post-weaning undernutrition (marasmus). Virus-infected marasmic mice have an increased incidence of mortality, severe lesions, and elevated and persistent viral titers in target organs.

Effect of concurrent cytomegaloviral infection and undernutrition on the growth and immune response of mice

“…29:579, 1970) indicates that the interaction of infection and undernutrition is also important before birth. The observations on humans are supported by experimental investigations with animals that have shown severe impairment of the immune system resulting from acute undernutrition (2, 33,34) or infection (15,25).…”

The Effect of Protein‐deprivation on the Susceptibility to Influenza Virus Infection: A Murine Model System

“…With coxsackie B3 virus, transfer of immune splenic Iymphoid cells from well-nourished donors significantly reduced the incidence of mortality and of lesions in target organs of protein-deprived mice, which strongly suggested that the increased severity of infection was due to an impaired cell-mediated immune responsiveness (Woodruff and Woodruff, 1971).…”

“…An increased viraemia, viral persistence and viral invasiveness have also been observed in protein-deprived mice infected with coxsackie B3 virus (Woodruff and Kilbourne, 1970;Woodruff and Woodruff, 1971) and herpes simplex virus (Katz and Plotkin, 1967), and a depressed immune response has been reported in rats infected with louping ill virus with decreased viral clearance (Miles, 1951). With coxsackie B3 virus, transfer of immune splenic Iymphoid cells from well-nourished donors significantly reduced the incidence of mortality and of lesions in target organs of protein-deprived mice, which strongly suggested that the increased severity of infection was due to an impaired cell-mediated immune responsiveness (Woodruff and Woodruff, 1971).…”

Mapping of a quantitative trait locus controlling susceptibility to Coxsackievirus B3-induced viral hepatitis

“…Natural variation in response to Coxsackievirus in the mouse model is diverse, and depends on host genetic factors, 8,18-20,30 viral genetic factors [31][32][33] and also environmental factors such as age, 34 sex 35,36 or diet. 37,38 To study host genetic factors which determine ability to control infection within relatively resistant B6 and relatively susceptible A/J mice, we have made use of a RC strain panel. 39 In a typical RC strain study, 21,40 strains are compared against their respective genetic background (for example, BcA vs B6 and AcB vs A/J) to identify discordant strains.…”